CBD Farmacêutico

termo de indexação original: Pharma CBD

O que é CBD Farmacêutico

CBD Farmacêutico marca os estudos feitos com canabidiol purificado em formulação medicamentosa, com dose definida e controle de qualidade — em oposição a extratos de espectro amplo ou produtos de consumo.

O exemplo mais estudado é o CBD purificado aprovado para formas raras e graves de epilepsia, entre elas as síndromes de Dravet e de Lennox-Gastaut. Foi o primeiro medicamento derivado da cannabis aprovado por agências reguladoras de referência com base em ensaios clínicos randomizados.

É a categoria com a literatura de melhor qualidade metodológica dentro do acervo, porque medicamento registrado exige ensaios controlados por placebo. Ao comparar resultados, vale lembrar que as doses usadas nesses estudos costumam ser bem mais altas que as de produtos de consumo.

No acervo

O acervo do Cannabis Indica reúne 161 estudos científicos que tocam o composto CBD Farmacêutico, publicados entre 2007 e 2024. Pela leitura automatizada, 122 (76%) foram classificados como favoráveis, 26 (16%) como inconclusivos e 13 (8%) como desfavoráveis — uma leitura de máquina, feita para navegar, não para concluir. O desenho mais frequente é metanálise (69 estudos), seguido de ensaio clínico (33). As condições mais associadas são Epilepsia, Epilepsia — Síndrome de Dravet e Epilepsia — Lennox-Gastaut.

Estudos indexados: 161
Período coberto: 2007–2024
Favoráveis: 122 · 76%
Inconclusivos: 26 · 16%
Desfavoráveis: 13 · 8%
Termo original: Pharma CBD

O acervo em números

Tipo de estudo

Metanálise69

Ensaio Clínico33

Metanálise Clínica27

Ensaio Clínico Duplo-Cego24

Estudo Laboratorial5

Estudo em Animais3

Direção do resultado

Favorável122

Inconclusivo26

Desfavorável13

Por década

2000s1

2010s26

2020s134

Aparece junto com

Epilepsia94 Epilepsia — Síndrome de Dravet55 Epilepsia — Lennox-Gastaut54 Dor44 Câncer24 Ansiedade24 Inflamação22 Efeitos Adversos da Cannabis21

161 estudos

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2024
Alzheimer's disease, aging, and cannabidiol treatment: a promising path to promote brain health and delay aging
FavorávelMetanáliseInflamação Estresse Oxidativo Doenças Neurodegenerativas+3
2024
Assessment of Clinical Outcomes in Patients With Osteoarthritis: Analysis From the UK Medical Cannabis Registry
FavorávelMetanáliseDor Ansiedade Insônia e Distúrbios do Sono THC Farmacêutico THC:CBD Farmacêutico+1
2024
Cannabidiol for behavior symptoms in Alzheimer’s disease (CANBiS-AD): a randomized, double-blind, placebo-controlled trial
FavorávelEnsaio ClínicoAnsiedade Doença de Alzheimer Transtornos de Comportamento+1
2024
Cannabidiol Intervention for Muscular Tension, Pain, and Sleep Bruxism Intensity-A Randomized, Double-Blind Clinical Trial
FavorávelEnsaio Clínico Duplo-CegoDor Insônia e Distúrbios do Sono Disfunção Temporomandibular (DTM)
2024
Cannabidiol: metabolism and clinical efficacy in epileptic patients
FavorávelMetanáliseEpilepsia
2024
Cannabinoid treatment for the symptoms of autism spectrum disorder
InconclusivoMetanáliseAutismo Síndrome do X Frágil Canabidiol (CBD)
2024
The efficacy and safety of cannabidiol (CBD) in pediatric patients with Dravet Syndrome: a narrative review of clinical trials
FavorávelMetanálise ClínicaEpilepsia Epilepsia — Síndrome de Dravet
2024
The Therapeutic Potential of Cannabidiol in Revolutionising Opioid Use Disorder Management
FavorávelMetanáliseDependência Química Dependência — Opioides Endocanabinoide (não especificado)Canabidiol (CBD)
2024
Transdermal Delivery of Cannabidiol for the Management of Acute Inflammatory Pain: A Comprehensive Review of the Literature
FavorávelMetanáliseDor Dor — Polineuropatia Inflamatória Dor — Dentária Aguda
2023
A Randomized, Controlled Trial of Efficacy and Safety of Cannabidiol in Idiopathic and Diabetic Gastroparesis
FavorávelEnsaio Clínico Duplo-CegoDiabetes Gastroparesia Hidrolase de Amidas de Ácidos Graxos (FAAH)
2023
Biotechnological Fungal Platforms for the Production of Biosynthetic Cannabinoids
FavorávelEstudo LaboratorialDor Câncer Inflamação Tetraidrocanabinol (THC)THC Farmacêutico+25
2023
Cannabidiol as an Adjunct to Botulinum Toxin in Blepharospasm - A Randomized Pilot Study
FavorávelEnsaio Clínico Duplo-CegoDor Câncer Dor — Crônica THC Farmacêutico THC:CBD Farmacêutico+8
2023
Cannabidiol as an Alternative Analgesic for Acute Dental Pain
FavorávelEnsaio Clínico Duplo-CegoDor Dor — Aguda Doença Periodontal+2
2023
Cannabidiol safety considerations: Development of a potential acceptable daily intake value and recommended upper intake limits for dietary supplement use
FavorávelEnsaio ClínicoDor Câncer Efeitos Adversos da Cannabis Tetraidrocanabinol (THC)THC:CBD Farmacêutico+10
2023
Cannabidiol Treatment for Neurological, Cognitive, and Psychiatric Symptoms in Sturge-Weber Syndrome
FavorávelEnsaio ClínicoAnsiedade Síndrome de Sturge-Weber
2023
Cannabidiol-enriched cannabis extraction product in Parkinson's disease: A randomized, double-blind, and placebo-controlled trial in Buriram Hospital
FavorávelEnsaio Clínico Duplo-CegoAnsiedade Depressão Doença de Parkinson+2
2023
Cannabidiol: Bridge between Antioxidant Effect, Cellular Protection, and Cognitive and Physical Performance
FavorávelMetanáliseDor Inflamação Ansiedade Anandamida (AEA)Endocanabinoide (não especificado)+23
2023
Cannabis-opioid interaction in the treatment of fibromyalgia pain: an open-label, proof of concept study with randomization between treatment groups: cannabis, oxycodone or cannabis/oxycodone combination-the SPIRAL study
InconclusivoMetanáliseDependência Química Dor — Crônica Dependência — Opioides THC Farmacêutico THC:CBD Farmacêutico+1
2023
Climbing the Evidence Pyramid: Dosing Considerations for Medical Cannabis in the Management of Chronic Pain
FavorávelMetanáliseDor Dor — Crônica Tetraidrocanabinol (THC)THC Farmacêutico+1
2023
Clinical efficacy and safety of cannabidiol for pediatric refractory epilepsy indications: A systematic review and meta-analysis
FavorávelMetanálise ClínicaEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2023
Dramatic efficacy of cannabidiol on refractory chronic pain in an adolescent with sickle cell disease
FavorávelMetanáliseDor Ansiedade Dor — Crônica Canabinoide Sintético (não especificado)+4
2023
Effect of Cannabidiol Oil on Post-ureteroscopy Pain for Urinary Calculi: A Randomized, Double-blind, Placebo-controlled Trial
InconclusivoEnsaio Clínico Duplo-CegoDor Inflamação Dor — Aguda+1
2023
Effects of Chronic, Low-Dose Cannabinoids, Cannabidiol, Delta-9-Tetrahydrocannabinol and a Combination of Both, on Amyloid Pathology in the 5xFAD Mouse Model of Alzheimer's Disease
InconclusivoEstudo em AnimaisDoença de Alzheimer THC Farmacêutico THC:CBD Farmacêutico
2023
Endocannabinoid System and Exogenous Cannabinoids in Depression and Anxiety: A Review
InconclusivoMetanáliseDor Câncer Inflamação Anandamida (AEA)Endocanabinoide (não especificado)+26
2023
Establishment of a point of departure for CBD hepatotoxicity employing human HepaRG spheroids
InconclusivoEstudo LaboratorialCâncer Inflamação Epilepsia Tetraidrocanabinol (THC)+4
2023
Impact of cannabidiol on reward- and stress-related neurocognitive processes among individuals with opioid use disorder: A pilot, double-blind, placebo-controlled, randomized cross-over trial
FavorávelEnsaio Clínico Duplo-CegoDependência Química Disfunção Cognitiva Dependência — Opioides+1
2023
Medical Cannabis Received by Patients According to Qualifying Condition in a US State Cannabis Program: Product Choice, Dosing, and Age-Related Trends
FavorávelMetanáliseDor Câncer Dor — Crônica THC Farmacêutico+17
2023
Pharmacotherapy for Dravet Syndrome: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
FavorávelMetanálise ClínicaEpilepsia Epilepsia — Síndrome de Dravet
2023
Phytocannabinoids: Pharmacological effects, biomedical applications, and worldwide prospection
InconclusivoMetanálise ClínicaDor Câncer Ansiedade THC Farmacêutico THC:CBD Farmacêutico+9
2023
Poster 186: Cannabidiol for Post-Operative Pain Control after Arthroscopic Rotator Cuff Repair Demonstrates No Functional Deficits at 1-Year
FavorávelEnsaio Clínico Duplo-CegoDor Dor — Aguda
2023
Seizure-free days as a novel outcome in patients with Lennox-Gastaut syndrome: Post hoc analysis of patients receiving cannabidiol in two randomized controlled trials
FavorávelMetanálise ClínicaEpilepsia Epilepsia — Lennox-Gastaut
2023
The Effects of Pharmacological Treatment of Nightmares: A Systematic Literature Review and Meta-Analysis of Placebo-Controlled, Randomized Clinical Trials
FavorávelMetanálise ClínicaAnsiedade Depressão Insônia e Distúrbios do Sono Tetraidrocanabinol (THC)+1
2023
Trial of a Novel Oral Cannabinoid Formulation in Patients with Hypertension: A Double-Blind, Placebo-Controlled Pharmacogenetic Study
FavorávelEnsaio Clínico Duplo-CegoCâncer Doenças Cardiovasculares (DCV)Hipertensão Arterial Canabinoide Sintético (não especificado)
2023
Use of non-medical cannabis in epilepsy: A scoping review
InconclusivoMetanáliseEpilepsia Esclerose Múltipla Doença de Alzheimer+3
2022
A Practical Guide to the Treatment of Dravet Syndrome with Anti-Seizure Medication
FavorávelMetanáliseEpilepsia Disfunção Cognitiva Epilepsia — Síndrome de Dravet
2022
A Review on the Bioactivity of Cannabinoids on Zebrafish Models: Emphasis on Neurodevelopment
FavorávelMetanáliseDor Câncer Ansiedade Anandamida (AEA)Tetraidrocanabinol (THC)+25
2022
Adverse Effects of Oral Cannabidiol: An Updated Systematic Review of Randomized Controlled Trials (2020-2022)
FavorávelMetanálise ClínicaEfeitos Adversos da Cannabis
2022
Cannabinoids: Therapeutic Use in Clinical Practice
FavorávelMetanálise ClínicaCâncer Epilepsia Doenças Neurodegenerativas Anandamida (AEA)Tetraidrocanabinol (THC)+16
2022
Cannabis and cannabinoids for symptomatic treatment for people with multiple sclerosis
InconclusivoMetanálise ClínicaDor Dor — Crônica Psicose THC Farmacêutico THC:CBD Farmacêutico+1
2022
Cannabis in Parkinson's Disease - the patient's perspective versus clinical trials: a systematic literature review
DesfavorávelMetanálise ClínicaDor Inflamação Ansiedade Anandamida (AEA)Endocanabinoide (não especificado)+5
2022
Cannabis-Based Products for Chronic Pain : A Systematic Review
FavorávelMetanálise ClínicaDor Inflamação Dependência — Cannabis Tetraidrocanabinol (THC)THC Farmacêutico+7
2022
Cannabis-Based Products for the Treatment of Skin Inflammatory Diseases: A Timely Review
FavorávelMetanáliseDor Câncer Inflamação Anandamida (AEA)Tetraidrocanabinol (THC)+28
2022
Does Cannabidiol Have a Benefit as a Supportive Care Drug in Cancer?
FavorávelMetanáliseDor Câncer Efeitos Adversos da Cannabis Anandamida (AEA)Endocanabinoide (não especificado)+19
2022
Effects of Epidiolex® (Cannabidiol) on seizure-related emergency department visits and hospital admissions: A retrospective cohort study
FavorávelMetanáliseEpilepsia
2022
Endothelial dysfunction and angiogenesis: what is missing from COVID-19 and cannabidiol story?
FavorávelMetanáliseInflamação Epilepsia Esclerose Múltipla Tetraidrocanabinol (THC)Endocanabinoide (não especificado)+7
2022
In vitro percutaneous absorption studies of cannabidiol using human skin: Exploring the effect of drug concentration, chemical enhancers, and essential oils
FavorávelEstudo LaboratorialDor Câncer Inflamação Anandamida (AEA)2-Araquidonoilglicerol (2-AG)+14
2022
Is There a Place for Medicinal Cannabis in Treating Patients with Sleep Disorders? What We Know so Far
FavorávelMetanálise ClínicaInsônia e Distúrbios do Sono Apneia do Sono Síndrome das Pernas Inquietas Tetraidrocanabinol (THC)THC Farmacêutico+3
2022
Long-term observational studies with cannabis-based medicines for chronic non-cancer pain: A systematic review and meta-analysis of effectiveness and safety
FavorávelMetanáliseDor Ansiedade Dor — Crônica Hidrolase de Amidas de Ácidos Graxos (FAAH)THC Farmacêutico+5
2022
Low-Dose Delta-9-Tetrahydrocannabinol as Beneficial Treatment for Aged APP/PS1 Mice
FavorávelEstudo em AnimaisDisfunção Cognitiva Doenças Neurodegenerativas Doença de Alzheimer THC Farmacêutico+1
2022
Movement Disorders Secondary to Novel Antiseizure Medications in Pediatric Populations: A Systematic Review and Meta-analysis of Risk
InconclusivoMetanálise ClínicaEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2022
Pain response to cannabidiol in induced acute nociceptive pain, allodynia, and hyperalgesia by using a model mimicking acute pain in healthy adults in a randomized trial (CANAB I)
InconclusivoEnsaio Clínico Duplo-CegoDor Dor — Aguda
2022
Pain response to cannabidiol in opioid-induced hyperalgesia, acute nociceptive pain, and allodynia using a model mimicking acute pain in healthy adults in a randomized trial (CANAB II)
DesfavorávelEnsaio Clínico Duplo-CegoDor Inflamação Epilepsia+1
2022
Pharmacokinetic Profile of ∆9-Tetrahydrocannabinol, Cannabidiol and Metabolites in Blood following Vaporization and Oral Ingestion of Cannabidiol Products
InconclusivoEnsaio Clínico Duplo-Cego
2022
Practical Considerations for the Use of Cannabis in Cancer Pain Management—What a Medical Oncologist Should Know
FavorávelMetanáliseDor Câncer Epilepsia Anandamida (AEA)2-Araquidonoilglicerol (2-AG)+14
2022
Preclinical Assessment of the Abuse Potential of Purified Botanical Cannabidiol: Self-Administration, Drug Discrimination, and Physical Dependence
FavorávelMetanáliseDependência Química Efeitos Adversos da Cannabis Dependência — Cannabis+1
2022
Prescription cannabidiol for seizure disorder management: Initial drug-drug interaction management by specialty pharmacists
FavorávelMetanáliseEfeitos Adversos da Cannabis Epilepsia Epilepsia — Lennox-Gastaut
2022
Quantitative electroencephalographic analysis as a potential biomarker of response to treatment with cannabidiol
FavorávelEnsaio ClínicoEfeitos Adversos da Cannabis Doenças Cardiovasculares (DCV)Epilepsia+1
2022
Randomized controlled trials on the use of cannabis-based medicines in movement disorders: a systematic review
FavorávelMetanálise ClínicaAnsiedade Insônia e Distúrbios do Sono Doença de Parkinson THC Farmacêutico+6
2022
Safety and Tolerability of Oral Cannabinoids in People Living with HIV on Long-Term ART: A Randomized, Open-Label, Interventional Pilot Clinical Trial (CTNPT 028)
FavorávelEnsaio ClínicoInflamação HIV/AIDS Hepatite Tetraidrocanabinol (THC)THC:CBD Farmacêutico
2022
Safety, Pharmacokinetics and Pharmacodynamics of Spectrum Yellow Oil in Healthy Participants
FavorávelEnsaio ClínicoEfeitos Adversos da Cannabis Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut Tetraidrocanabinol (THC)THC:CBD Farmacêutico+2
2022
Shifting the Paradigm on Cannabis Safety
DesfavorávelMetanáliseCâncer Inflamação Efeitos Adversos da Cannabis+17
2022
The effect of medical cannabis on cognitive functions: a systematic review
DesfavorávelMetanálise ClínicaDor Câncer Efeitos Adversos da Cannabis THC:CBD Farmacêutico Canabinol (CBN)+11
2022
The Effectiveness and Safety of Cannabidiol in Non-seizure-related Indications: A Systematic Review of Published Randomized Clinical Trials
InconclusivoMetanálise ClínicaDependência Química Ansiedade Epilepsia Tetraidrocanabinol (THC)+2
2022
Therapeutic Potential of Cannabis, Cannabidiol, and Cannabinoid-Based Pharmaceuticals
FavorávelMetanáliseDor Dependência — Cannabis Dor — Crônica THC Farmacêutico THC:CBD Farmacêutico+9
2022
TRPV1: A Common Denominator Mediating Antinociceptive and Antiemetic Effects of Cannabinoids
FavorávelMetanáliseDor Inflamação Efeitos Adversos da Cannabis Anandamida (AEA)Endocanabinoide (não especificado)+18
2022
Use of cannabidiol in the treatment of epilepsy: Lennox-Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex
FavorávelMetanálise ClínicaEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2022
What Do We Know About Medical Cannabis in Neurological Disorders and What Are the Next Steps?
FavorávelMetanáliseInflamação Estresse Oxidativo Doenças Neurodegenerativas Endocanabinoide (não especificado)Canabinoide Sintético (não especificado)+5
2022
Why Do Marijuana and Synthetic Cannabimimetics Induce Acute Myocardial Infarction in Healthy Young People?
DesfavorávelMetanáliseEfeitos Adversos da Cannabis Doenças Cardiovasculares (DCV)Infarto Anandamida (AEA)Tetraidrocanabinol (THC)+16
2021
A Mapping Literature Review of Medical Cannabis Clinical Outcomes and Quality of Evidence in Approved Conditions in the USA from 2016 to 2019
InconclusivoMetanáliseDor Câncer Dor — Crônica THC Farmacêutico+10
2021
A Phase 1 Open-Label, Fixed-Sequence Pharmacokinetic Drug Interaction Trial to Investigate the Effect of Cannabidiol on the CYP1A2 Probe Caffeine in Healthy Subjects
DesfavorávelEnsaio ClínicoEpilepsia Epilepsia — Lennox-Gastaut
2021
A primer on medicinal cannabis safety and potential adverse effects
InconclusivoMetanáliseEfeitos Adversos da Cannabis Dependência — Cannabis Doenças Cardiovasculares (DCV)THC Farmacêutico+2
2021
Add-on Cannabidiol Treatment for Drug-Resistant Seizures in Tuberous Sclerosis Complex
FavorávelEnsaio Clínico Duplo-CegoEpilepsia
2021
Anti-seizure medications for Lennox-Gastaut syndrome
InconclusivoMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2021
Approved cannabinoids for medical purposes - Comparative systematic review and meta-analysis for sleep and appetite
InconclusivoMetanálise ClínicaEfeitos Adversos da Cannabis Insônia e Distúrbios do Sono Anorexia (perda de apetite)THC Farmacêutico
2021
Assessments and Interventions for Sleep Disorders in Infants With or at High Risk for Cerebral Palsy: A Systematic Review
InconclusivoMetanáliseInsônia e Distúrbios do Sono Paralisia Cerebral THC Farmacêutico
2021
Can Cannabidiol Affect the Efficacy of Chemotherapy and Epigenetic Treatments in Cancer?
FavorávelMetanáliseDor Câncer Inflamação+6
2021
Cannabidiol and Abnormal Liver Chemistries in Healthy Adults: Results of a Phase I Clinical Trial
FavorávelMetanáliseEfeitos Adversos da Cannabis Epilepsia Epilepsia — Síndrome de Dravet+2
2021
Cannabidiol as prophylaxis for SARS-CoV-2 and COVID-19? Unfounded claims versus potential risks of medications during the pandemic
DesfavorávelMetanáliseInflamação Doenças Neurodegenerativas Infecções Bacterianas+1
2021
Cannabidiol in conjunction with clobazam: analysis of four randomized controlled trials
FavorávelEnsaio Clínico Duplo-CegoEpilepsia
2021
Cannabidiol in Pharmacoresistant Epilepsy: Clinical Pharmacokinetic Data From an Expanded Access Program
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2021
Cannabidiol in the Treatment of Epilepsy
FavorávelMetanáliseEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2021
Cannabidiol Interactions with Medications, Illicit Substances, and Alcohol: a Comprehensive Review
DesfavorávelMetanáliseDepressão Epilepsia Dependência — Opioides+4
2021
Cost-Effectiveness of Medicinal Cannabis for Management of Refractory Symptoms Associated With Chronic Conditions: A Systematic Review of Economic Evaluations
FavorávelMetanáliseDor Dor — Crônica Epilepsia THC Farmacêutico THC:CBD Farmacêutico+7
2021
Cytochrome P450-Catalyzed Metabolism of Cannabidiol to the Active Metabolite 7-Hydroxy-Cannabidiol
DesfavorávelEstudo LaboratorialEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut+2
2021
Delivering therapeutic cannabinoids via skin: Current state and future perspectives
FavorávelMetanáliseTHC Farmacêutico THC:CBD Farmacêutico
2021
Developmental cannabidiol exposure increases anxiety and modifies genome-wide brain DNA methylation in adult female mice
InconclusivoEstudo em AnimaisAnsiedade Disfunção Cognitiva Gestação+1
2021
Effect of Cannabidiol on Interictal Epileptiform Activity and Sleep Architecture in Children with Intractable Epilepsy: A Prospective Open-Label Study
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2021
Efficacy and safety of medical cannabinoids in children: a systematic review and meta-analysis
FavorávelMetanáliseEfeitos Adversos da Cannabis Epilepsia Epilepsia — Síndrome de Dravet THC Farmacêutico THC:CBD Farmacêutico+2
2021
Efficacy and safety of paediatric medicinal cannabis use: A scoping review
DesfavorávelMetanáliseDor Câncer Epilepsia THC Farmacêutico+7
2021
Epileptic Phenotype and Cannabidiol Efficacy in a Williams–Beuren Syndrome Patient With Atypical Deletion: A Case Report
FavorávelMetanáliseEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2021
Food effects on the formulation, dosing, and administration of cannabidiol (CBD) in humans: A systematic review of clinical studies
InconclusivoMetanálise
2021
Global Trends in Cannabis and Cannabidiol Research from the Year 1940 to 2019
FavorávelMetanálise
2021
Improved Bioavailability with Dry Powder Cannabidiol Inhalation: A Phase 1 Clinical Study
FavorávelEnsaio ClínicoDor Ansiedade Dor — Crônica+4
2021
Long-term cannabidiol treatment for seizures in patients with tuberous sclerosis complex: An open-label extension trial
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2021
Long-term safety and efficacy of add-on cannabidiol in patients with Lennox-Gastaut syndrome: Results of a long-term open-label extension trial
FavorávelEnsaio Clínico Duplo-CegoEpilepsia Epilepsia — Lennox-Gastaut
2021
Long-term safety and efficacy of highly purified cannabidiol for treatment refractory epilepsy
FavorávelEnsaio ClínicoEpilepsia
2021
Longitudinal impact of cannabidiol on EEG measures in subjects with treatment-resistant epilepsy
FavorávelEnsaio ClínicoEpilepsia
2021
Medical cannabinoids for treatment of neuropsychiatric symptoms in dementia: a systematic review
FavorávelMetanáliseDisfunção Cognitiva Doenças Neurodegenerativas Insônia e Distúrbios do Sono THC Farmacêutico THC:CBD Farmacêutico+5
2021
Medicinal applications of cannabis/cannabinoids
InconclusivoMetanáliseDor Epilepsia Insônia e Distúrbios do Sono
2021
Natural and Synthetic Cannabinoids: Pharmacology, Uses, Adverse Drug Events, and Drug Interactions
DesfavorávelMetanáliseDor Dependência Química Efeitos Adversos da Cannabis 2-Araquidonoilglicerol (2-AG)Canabinoide Sintético (não especificado)+24
2021
New Pharmacological Targets for the Treatment of Schizophrenia: A Literature Review
FavorávelMetanálisePsicose Esquizofrenia
2021
New therapeutic approach in Dravet syndrome and Lennox-Gastaut syndrome with cannabidiol
FavorávelMetanáliseEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2021
Results From an Italian Expanded Access Program on Cannabidiol Treatment in Highly Refractory Dravet Syndrome and Lennox–Gastaut Syndrome
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2021
Role of Cannabidiol in the Therapeutic Intervention for Substance Use Disorders
FavorávelMetanáliseDependência — Cannabis Disfunção Cognitiva Psicose Anandamida (AEA)2-Araquidonoilglicerol (2-AG)+9
2021
Safety and efficacy of low-dose medical cannabis oils in multiple sclerosis
FavorávelEnsaio ClínicoEsclerose Múltipla THC Farmacêutico THC:CBD Farmacêutico
2021
Seizure frequency, quality of life, behavior, cognition, and sleep in pediatric patients enrolled in a prospective, open-label clinical study with cannabidiol
FavorávelEnsaio ClínicoEpilepsia Insônia e Distúrbios do Sono Transtornos de Comportamento
2021
The Effectiveness of Cannabis and Cannabis Derivatives in Treating Lower Back Pain in the Aged Population: A Systematic Review
InconclusivoMetanáliseDor Ansiedade Dor — Crônica THC Farmacêutico+3
2021
The long-term efficacy of cannabidiol in the treatment of refractory epilepsy
FavorávelMetanáliseEpilepsia
2021
Time to onset of cannabidiol (CBD) treatment effect in Lennox–Gastaut syndrome: Analysis from two randomized controlled trials
FavorávelMetanálise ClínicaEpilepsia Epilepsia — Lennox-Gastaut
2021
Time to onset of cannabidiol treatment effects in Dravet syndrome: Analysis from two randomized controlled trials
FavorávelMetanálise ClínicaEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2021
Two-center experience of cannabidiol use in adults with Dravet syndrome
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut+1
2021
UHPLC-MS/MS Analysis of Cannabidiol and Its Metabolites in Serum of Patients with Resistant Epilepsy Treated with CBD Formulations
InconclusivoEstudo LaboratorialEpilepsia
2021
Understanding the complex pharmacology of cannabidiol: Mounting evidence suggests a common binding site with cholesterol
InconclusivoMetanáliseDoenças Cardiovasculares (DCV)Infarto Hidrolase de Amidas de Ácidos Graxos (FAAH)
2021
Understanding the Modulatory Effects of Cannabidiol on Alzheimer’s Disease
FavorávelMetanáliseDisfunção Cognitiva Doenças Neurodegenerativas Doença de Alzheimer
2021
White matter integrity after cannabidiol administration for treatment resistant epilepsy
FavorávelEnsaio ClínicoEpilepsia
2020
A Phase 2, Double-Blind, Placebo-Controlled Trial to Investigate Potential Drug-Drug Interactions Between Cannabidiol and Clobazam
FavorávelEnsaio Clínico Duplo-CegoEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2020
A Phase I, Open-Label, Parallel-Group, Single-Dose Trial of the Pharmacokinetics, Safety, and Tolerability of Cannabidiol in Subjects with Mild to Severe Renal Impairment
FavorávelEnsaio ClínicoEfeitos Adversos da Cannabis Epilepsia Epilepsia — Síndrome de Dravet+2
2020
A Phase II Randomized Trial to Explore the Potential for Pharmacokinetic Drug-Drug Interactions with Stiripentol or Valproate when Combined with Cannabidiol in Patients with Epilepsy
FavorávelEnsaio Clínico Duplo-CegoEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2020
Abrupt withdrawal of cannabidiol (CBD): A randomized trial
FavorávelEnsaio Clínico Duplo-CegoDependência Química Efeitos Adversos da Cannabis Dependência — Cannabis
2020
Cannabidiol Drugs Clinical Trial Outcomes and Adverse Effects
FavorávelMetanálise ClínicaDependência — Cannabis Epilepsia Dependência — Opioides+3
2020
Cannabidiol efficacy independent of clobazam: Meta-analysis of four randomized controlled trials
FavorávelMetanálise ClínicaEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2020
Cannabidiol for epilepsy (Lennox-Gastaut syndrome, Dravet syndrome)
FavorávelMetanálise ClínicaEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2020
Cannabidiol normalizes resting-state functional connectivity in treatment-resistant epilepsy
FavorávelEnsaio ClínicoEpilepsia
2020
Cannabinoids for People with ASD: A Systematic Review of Published and Ongoing Studies
FavorávelMetanáliseAutismo THC Farmacêutico THC:CBD Farmacêutico
2020
Cognitive function and adaptive skills after a one-year trial of cannabidiol (CBD) in a pediatric sample with treatment-resistant epilepsy
FavorávelEnsaio ClínicoEpilepsia Disfunção Cognitiva Transtornos de Comportamento
2020
Cutaneous Adverse Events in Newly Approved FDA Non-cancer Drugs: A Systematic Review
DesfavorávelMetanáliseEfeitos Adversos da Cannabis Doenças de Pele
2020
Does cannabidiol have antiseizure activity independent of its interactions with clobazam? An appraisal of the evidence from randomized controlled trials
FavorávelMetanálise ClínicaEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2020
Dose-Ranging Effect of Adjunctive Oral Cannabidiol vs Placebo on Convulsive Seizure Frequency in Dravet Syndrome: A Randomized Clinical Trial
FavorávelEnsaio Clínico Duplo-CegoEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2020
Effect of Cannabinoids on Electroencephalography of a Child with Lennox-Gastaut Syndrome
FavorávelMetanáliseEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2020
It Is Our Turn to Get Cannabis High: Put Cannabinoids in Food and Health Baskets
FavorávelMetanáliseTHC Farmacêutico THC:CBD Farmacêutico+4
2020
Lennox–Gastaut Syndrome: Perspective of a Parent and a Physician
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2020
Pharmacogenetic Predictors of Cannabidiol Response and Tolerability in Treatment-Resistant Epilepsy
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2020
Pharmacotherapeutic Considerations for Use of Cannabinoids to Relieve Symptoms of Nausea and Vomiting Induced by Chemotherapy
FavorávelMetanálise ClínicaNáusea e Vômito Síndrome da Hiperêmese Canabinoide Tetraidrocanabinol (THC)THC Farmacêutico+2
2020
Towards Better Delivery of Cannabidiol (CBD)
InconclusivoMetanálise
2019
A Comprehensive Review of Cannabis in Patients with Cancer: Availability in the USA, General Efficacy, and Safety
InconclusivoMetanáliseDor Câncer Epilepsia+2
2019
A Multicriteria Decision Analysis Comparing Pharmacotherapy for Chronic Neuropathic Pain, Including Cannabinoids and Cannabis-Based Medical Products
FavorávelMetanáliseDor Dor — Crônica THC Farmacêutico THC:CBD Farmacêutico
2019
A Phase 1, Open-Label, Pharmacokinetic Trial to Investigate Possible Drug-Drug Interactions Between Clobazam, Stiripentol, or Valproate and Cannabidiol in Healthy Subjects
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2019
A phase 1/2, open-label assessment of the safety, tolerability, and efficacy of transdermal cannabidiol (ZYN002) for the treatment of pediatric fragile X syndrome
FavorávelEnsaio ClínicoSíndrome do X Frágil
2019
Assay of plasma cannabidiol by capillary gas chromatography/ion trap mass spectroscopy following high-dose repeated daily oral administration in humans
FavorávelEnsaio Clínico Duplo-CegoDistrofia Muscular e Distúrbios Miotônicos
2019
Cannabidiol in patients with Lennox-Gastaut syndrome: Interim analysis of an open-label extension study
FavorávelEnsaio Clínico Duplo-CegoEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2019
Examination of a New Delivery Approach for Oral Cannabidiol in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Pharmacokinetics Study
FavorávelEnsaio Clínico Duplo-CegoDoenças Cardiovasculares (DCV)Hipertensão Arterial
2019
Long-term cannabidiol treatment in patients with Dravet syndrome: An open-label extension trial
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Síndrome de Dravet Perda de Apetite+2
2019
Long-term safety and efficacy of cannabidiol in children and adults with treatment resistant Lennox-Gastaut syndrome or Dravet syndrome: Expanded access program results
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut+1
2019
The Endocannabinoid System: A New Treatment Target for Obsessive Compulsive Disorder?
FavorávelMetanáliseTOC THC Farmacêutico THC:CBD Farmacêutico
2019
Treatment of Seizures Associated with Lennox-Gastaut and Dravet Syndromes: A Focus on Cannabidiol Oral Solution
FavorávelMetanáliseEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2019
US Veterinarians' Knowledge, Experience, and Perception Regarding the Use of Cannabidiol for Canine Medical Conditions
FavorávelMetanáliseDor Câncer Inflamação+17
2018
A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut Tetraidrocanabinol (THC)
2018
Abuse potential assessment of cannabidiol (CBD) in recreational polydrug users: A randomized, double-blind, controlled trial
FavorávelEnsaio Clínico Duplo-CegoEfeitos Adversos da Cannabis Epilepsia Disfunção Cognitiva THC Farmacêutico+6
2018
An interaction between warfarin and cannabidiol, a case report
FavorávelMetanáliseEpilepsia AVC Distúrbios de Coagulação
2018
Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer
FavorávelMetanáliseDor Câncer Inflamação Anandamida (AEA)2-Araquidonoilglicerol (2-AG)+5
2018
Report of Objective Clinical Responses of Cancer Patients to Pharmaceutical-grade Synthetic Cannabidiol
FavorávelMetanáliseCâncer Esclerose Múltipla Câncer — Mama THC:CBD Farmacêutico+5
2017
Cannabidiol as a Potential Treatment for Febrile Infection-Related Epilepsy Syndrome (FIRES) in the Acute and Chronic Phases.
FavorávelEnsaio ClínicoEpilepsia Epilepsia — FIRES
2017
Interactions between cannabidiol and commonly used antiepileptic drugs.
FavorávelEnsaio ClínicoEpilepsia
2017
Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome
FavorávelEnsaio Clínico Duplo-CegoEpilepsia Náusea e Vômito Epilepsia — Síndrome de Dravet+1
2016
Oral cannabidiol does not produce a signal for abuse liability in frequent marijuana smokers
FavorávelEnsaio ClínicoDor Dependência Química Câncer Anandamida (AEA)Hidrolase de Amidas de Ácidos Graxos (FAAH)+13
2015
Cannabis in the Treatment of Dystonia, Dyskinesias, and Tics
FavorávelMetanálise ClínicaTiques e Síndrome de Tourette Distonia Coreia Tetraidrocanabinol (THC)THC Farmacêutico
2015
Drug–drug interaction between clobazam and cannabidiol in children with refractory epilepsy
FavorávelEnsaio ClínicoEpilepsia
2014
Efficacy and Safety of Epidiolex (Cannabidiol) in Children and Young Adults with Treatment-Resistant Epilepsy: Initial Data From an Expanded Access Program.
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2014
Systematic review: efficacy and safety of medical marijuana in selected neurologic disorders: report of the Guideline Development Subcommittee of the American Academy of Neurology
FavorávelMetanálise ClínicaDor Epilepsia Esclerose Múltipla THC Farmacêutico THC:CBD Farmacêutico+5
2010
The interplay of cannabinoid and NMDA glutamate receptor systems in humans: preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects
DesfavorávelEnsaio ClínicoEsquizofrenia
2007
Cannabinoids in health and disease
FavorávelMetanáliseDor Inflamação Dependência — Cannabis Anandamida (AEA)Tetraidrocanabinol (THC)+25

Perguntas frequentes

Quantos estudos sobre cbd farmacêutico estão indexados no acervo?

São 161 estudos, publicados entre 2007 e 2024. O acervo inteiro tem 7.640 registros.

Que tipos de estudo predominam?

Metanálise: 69 · Ensaio Clínico: 33 · Metanálise Clínica: 27 · Ensaio Clínico Duplo-Cego: 24 · Estudo Laboratorial: 5 · Estudo em Animais: 3. A classificação segue o desenho declarado na fonte.

O que significa a classificação de resultado?

É uma leitura automatizada da conclusão de cada estudo, em três direções — favorável, inconclusivo e desfavorável. Aqui são 122 favoráveis, 26 inconclusivos e 13 desfavoráveis. Serve para navegar o acervo, não para concluir nada clinicamente: a conclusão válida é a do artigo original.

Como citar esta página

ABNT

CANNABIS INDICA. CBD Farmacêutico — estudos científicos sobre cannabis. 2026. Disponível em: https://cannabisindica.com.br/canabinoide/cbd-farmaceutico/. Acesso em: 13 set. 2026.

APA

Cannabis Indica. (2026). CBD Farmacêutico — estudos científicos sobre cannabis. https://cannabisindica.com.br/canabinoide/cbd-farmaceutico/

Esta página é um índice de acesso. Ao usar um estudo como evidência, cite o artigo original — o link de cada registro leva à fonte.