Epilepsia

termo de indexação original: Epilepsy

O acervo do Cannabis Indica reúne 460 estudos científicos que tocam a condição Epilepsia, publicados entre 1839 e 2024. Pela leitura automatizada, 368 (80%) foram classificados como favoráveis, 54 (12%) como inconclusivos e 38 (8%) como desfavoráveis — uma leitura de máquina, feita para navegar, não para concluir. O desenho mais frequente é metanálise (235 estudos), seguido de estudo em animais (84). Os compostos mais presentes são CBD Farmacêutico, Tetraidrocanabinol (THC) e Anandamida (AEA). Aparece com frequência ao lado de Epilepsia — Síndrome de Dravet, Epilepsia — Lennox-Gastaut e Dor.

Estudos indexados: 460
Período coberto: 1839–2024
Favoráveis: 368 · 80%
Inconclusivos: 54 · 12%
Desfavoráveis: 38 · 8%
Termo original: Epilepsy

O acervo em números

Tipo de estudo

Metanálise235

Estudo em Animais84

Ensaio Clínico62

Metanálise Clínica36

Ensaio Clínico Duplo-Cego23

Estudo Laboratorial20

Direção do resultado

Favorável368

Inconclusivo54

Desfavorável38

Por década

1830s1

1840s1

1850s1

1870s1

1890s1

1940s1

1970s9

1980s4

1990s2

2000s16

2010s137

2020s286

Aparece junto com

Epilepsia — Síndrome de Dravet142 Epilepsia — Lennox-Gastaut121 Dor81 Ansiedade80 Inflamação60 Câncer48 Depressão47 Náusea e Vômito45

460 estudos

Filtrar e buscar no acervo →

Esta página mostra 334 dos 460 estudos indexados sobre o tema, dos mais recentes aos mais antigos. Abra o acervo com este filtro para percorrer todos, ou baixe a lista completa em JSON e CSV.

2024
Cannabidiol-enriched oil for adult patients with drug-resistant epilepsy: Prospective clinical and electrophysiological study
FavorávelEnsaio ClínicoTetraidrocanabinol (THC)
2024
Cannabidiol: metabolism and clinical efficacy in epileptic patients
FavorávelMetanáliseCBD Farmacêutico
2024
Continuous spike-wave of slow sleep in a patient with KCNB1-related epilepsy responsive to highly purified cannabidiol: a case report and comparison with literature
FavorávelMetanáliseAutismo
2024
Dravet syndrome seizure frequency and clustering: Placebo-treated patients in clinical trials
FavorávelMetanálise ClínicaEpilepsia — Síndrome de Dravet
2024
Placebo response in patients with Dravet syndrome: Post-hoc analysis of two clinical trials
InconclusivoMetanálise ClínicaEpilepsia — Síndrome de Dravet
2024
The efficacy and safety of cannabidiol (CBD) in pediatric patients with Dravet Syndrome: a narrative review of clinical trials
FavorávelMetanálise ClínicaEpilepsia — Síndrome de Dravet CBD Farmacêutico
2024
The Use of Compounds Derived from Cannabis sativa in the Treatment of Epilepsy, Painful Conditions, and Neuropsychiatric and Neurodegenerative Disorders
FavorávelMetanáliseDor Inflamação Psicose Endocanabinoide (não especificado)+2
2024
TRPV1 channel in the pathophysiology of epilepsy and its potential as a molecular target for the development of new antiseizure drug candidates
FavorávelMetanálise
2023
A case of clinical worsening after stereo-electroencephalographic-guided radiofrequency thermocoagulation in a patient with polymicrogyria
FavorávelMetanálisePsicose
2023
A Case of Panic Attacks Developing After 10 Years of Chronic Cannabis Use in a Patient With No Prior Psychiatric History
DesfavorávelMetanáliseDor Câncer Inflamação Tetraidrocanabinol (THC)Canabigerol (CBG)+13
2023
A Rare Case of Cannabinoid Hyperemesis Syndrome Secondary to Cannabidiol for Refractory Epilepsy
DesfavorávelMetanáliseEfeitos Adversos da Cannabis Náusea e Vômito Síndrome da Hiperêmese Canabinoide+3
2023
A systematic review of cannabidiol trials in neurodevelopmental disorders
FavorávelMetanálise ClínicaDor Inflamação Ansiedade Anandamida (AEA)2-Araquidonoilglicerol (2-AG)+10
2023
Biotechnological Fungal Platforms for the Production of Biosynthetic Cannabinoids
FavorávelEstudo LaboratorialDor Câncer Inflamação Tetraidrocanabinol (THC)THC Farmacêutico+25
2023
Cannabidiol as an Adjunct to Botulinum Toxin in Blepharospasm - A Randomized Pilot Study
FavorávelEnsaio Clínico Duplo-CegoDor Câncer Dor — Crônica THC Farmacêutico THC:CBD Farmacêutico+8
2023
Cannabidiol safety considerations: Development of a potential acceptable daily intake value and recommended upper intake limits for dietary supplement use
FavorávelEnsaio ClínicoDor Câncer Efeitos Adversos da Cannabis Tetraidrocanabinol (THC)THC:CBD Farmacêutico+10
2023
Cannabidiol: Bridge between Antioxidant Effect, Cellular Protection, and Cognitive and Physical Performance
FavorávelMetanáliseDor Inflamação Ansiedade Anandamida (AEA)Endocanabinoide (não especificado)+23
2023
Clinical efficacy and safety of cannabidiol for pediatric refractory epilepsy indications: A systematic review and meta-analysis
FavorávelMetanálise ClínicaEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2023
Could cannabinoids provide a new hope for ovarian cancer patients?
FavorávelMetanáliseDor Câncer Inflamação Anandamida (AEA)2-Araquidonoilglicerol (2-AG)+24
2023
Effects of Cannabidiol on Innate Immunity: Experimental Evidence and Clinical Relevance
FavorávelMetanáliseCâncer Inflamação Ansiedade Canabigerol (CBG)Canabinol (CBN)+20
2023
Efficacy and tolerance of cannabidiol in the treatment of epilepsy in patients with Rett syndrome
FavorávelEnsaio ClínicoAnsiedade Síndrome de Rett
2023
Endocannabinoid System and Exogenous Cannabinoids in Depression and Anxiety: A Review
InconclusivoMetanáliseDor Câncer Inflamação Anandamida (AEA)Endocanabinoide (não especificado)+26
2023
Establishment of a point of departure for CBD hepatotoxicity employing human HepaRG spheroids
InconclusivoEstudo LaboratorialCâncer Inflamação Psicose Tetraidrocanabinol (THC)CBD Farmacêutico+3
2023
Exploring the therapeutic potential of an antinociceptive and anti-inflammatory peptide from wasp venom
FavorávelEstudo em AnimaisDor Inflamação Dor — Crônica Endocanabinoide (não especificado)Canabinoides Sintéticos AM-x+3
2023
Fenfluramine for Treating Dravet Syndrome: An Evidence Review Group Perspective of a NICE Single Technology Appraisal
FavorávelMetanáliseEpilepsia — Síndrome de Dravet Qualidade de Vida
2023
Instant Detection of Synthetic Cannabinoids on Physical Matrices, Implemented on a Low-Cost, Ultraportable Device
FavorávelEnsaio ClínicoDependência Química Efeitos Adversos da Cannabis Psicose Canabinoide Sintético (não especificado)Canabinoides Sintéticos 5F-x+5
2023
Medical Cannabis Received by Patients According to Qualifying Condition in a US State Cannabis Program: Product Choice, Dosing, and Age-Related Trends
FavorávelMetanáliseDor Câncer Dor — Crônica THC Farmacêutico CBD Farmacêutico+16
2023
Myoclonic super-refractory status epilepticus with favourable evolution in a teenager with FIRES: Is the association of vagus nerve stimulation and cannabidiol effective?
FavorávelMetanáliseEpilepsia — FIRES
2023
Pharmacotherapy for Dravet Syndrome: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
FavorávelMetanálise ClínicaEpilepsia — Síndrome de Dravet CBD Farmacêutico
2023
Phytocannabinoids: Pharmacological effects, biomedical applications, and worldwide prospection
InconclusivoMetanálise ClínicaDor Câncer Ansiedade THC Farmacêutico THC:CBD Farmacêutico+9
2023
Recurrent Severe Burns Due to Cannabinoid Hyperemesis Syndrome
DesfavorávelMetanáliseEfeitos Adversos da Cannabis Dependência — Cannabis Ansiedade Tetraidrocanabinol (THC)+7
2023
Reversible cerebral vasoconstriction syndrome associated with probable drug poisoning
DesfavorávelMetanáliseEfeitos Adversos da Cannabis Depressão Estresse Oxidativo Endocanabinoide (não especificado)+2
2023
Seizure-free days as a novel outcome in patients with Lennox-Gastaut syndrome: Post hoc analysis of patients receiving cannabidiol in two randomized controlled trials
FavorávelMetanálise ClínicaEpilepsia — Lennox-Gastaut CBD Farmacêutico
2023
The use of cannabidiol as a novel treatment for oral stereotypic behaviour (crib-biting) in a horse
FavorávelEstudo em AnimaisDor Inflamação Ansiedade Endocanabinoide (não especificado)+12
2023
Toxic Tetrahydrocannabinol (THC) Dose in Pediatric Cannabis Edible Ingestions
DesfavorávelMetanáliseEfeitos Adversos da Cannabis Doenças Cardiovasculares (DCV)Arritmias Cardíacas
2023
Turning down the spice: tackling the problems of synthetic cannabinoids
InconclusivoMetanáliseEfeitos Adversos da Cannabis Doenças Cardiovasculares (DCV)Psicose Tetraidrocanabinol (THC)Canabinoide Sintético (não especificado)+1
2023
Use of non-medical cannabis in epilepsy: A scoping review
InconclusivoMetanáliseEsclerose Múltipla Doença de Alzheimer Epilepsia — Síndrome de Dravet CBD Farmacêutico+2
2022
A Case of Synthetic Cannabinoid (K2)-Induced Posterior Reversible Encephalopathy Syndrome (PRES)
DesfavorávelMetanáliseEfeitos Adversos da Cannabis Ansiedade Doenças Cardiovasculares (DCV)Tetraidrocanabinol (THC)Canabinoide Sintético (não especificado)+4
2022
A narrative review of molecular mechanism and therapeutic effect of Cannabidiol (CBD)
FavorávelMetanáliseDor Câncer Inflamação+5
2022
A Practical Guide to the Treatment of Dravet Syndrome with Anti-Seizure Medication
FavorávelMetanáliseDisfunção Cognitiva Epilepsia — Síndrome de Dravet CBD Farmacêutico
2022
A randomized controlled trial assessing the safety and efficacy of palmitoylethanolamide for treating diabetic-related peripheral neuropathic pain
FavorávelEnsaio Clínico Duplo-CegoDor Inflamação Ansiedade Anandamida (AEA)Palmitoiletanolamida (PEA)+5
2022
A Review on the Bioactivity of Cannabinoids on Zebrafish Models: Emphasis on Neurodevelopment
FavorávelMetanáliseDor Câncer Ansiedade Anandamida (AEA)Tetraidrocanabinol (THC)+25
2022
A scoping review on cannabidiol therapy in tuberous sclerosis: Current evidence and perspectives for future development
FavorávelMetanálise
2022
Acute pancreatitis as a rare adverse event among cannabis users: A systematic review
DesfavorávelMetanáliseDor Inflamação Efeitos Adversos da Cannabis Anandamida (AEA)+16
2022
Adjunctive Transdermal Cannabidiol for Adults With Focal Epilepsy: A Randomized Clinical Trial
InconclusivoEnsaio Clínico Duplo-CegoEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2022
Adulteration of low-delta-9-tetrahydrocannabinol products with synthetic cannabinoids: Results from drug checking services
DesfavorávelEnsaio ClínicoEfeitos Adversos da Cannabis Ansiedade Doenças Cardiovasculares (DCV)Canabinoide Sintético (não especificado)Ácido Canabidiólico (CBD-a)+3
2022
Adverse events of recreational cannabis use during pregnancy reported to the French Addictovigilance Network between 2011 and 2020
DesfavorávelEnsaio ClínicoDependência Química Efeitos Adversos da Cannabis Dependência — Cannabis+12
2022
Antiseizure Effects of Cannabidiol Leading to Increased Peroxisome Proliferator-Activated Receptor Gamma Levels in the Hippocampal CA3 Subfield of Epileptic Rats
FavorávelEstudo em Animais
2022
Beta-caryophyllene attenuates short-term recurrent seizure activity and blood-brain-barrier breakdown after pilocarpine-induced status epilepticus in rats
FavorávelEstudo em Animais
2022
Biochemical aspects and therapeutic mechanisms of cannabidiol in epilepsy
FavorávelMetanáliseDoenças Neurodegenerativas Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2022
Breastfeeding while on treatment with antiseizure medications: a systematic review from the ILAE Women Task Force
FavorávelMetanálise ClínicaEfeitos Adversos da Cannabis Gestação
2022
Cannabidiol activates neuronal Kv7 channels
FavorávelEstudo Laboratorial
2022
Cannabidiol for the treatment of autism spectrum disorder: hope or hype?
FavorávelMetanáliseAnsiedade Depressão Doenças Neurodegenerativas Endocanabinoide (não especificado)+3
2022
Cannabidiol in canine epilepsy
InconclusivoMetanáliseDor Câncer Inflamação Ácido Canabidiólico (CBD-a)+7
2022
Cannabidiol in Treatment of Autism Spectrum Disorder: A Case Study
FavorávelMetanáliseAnsiedade Depressão Disfunção Cognitiva Anandamida (AEA)Tetraidrocanabinol (THC)+8
2022
Cannabidiol Increases Seizure Resistance and Improves Behavior in an Scn8a Mouse Model
FavorávelEstudo em AnimaisTranstornos de Comportamento Autismo TDA e TDAH
2022
Cannabinoids in rheumatology: Friend, foe or a bystander?
InconclusivoMetanáliseDor Dor — Crônica Esclerose Múltipla Anandamida (AEA)Tetraidrocanabinol (THC)+19
2022
Cannabinoids: Therapeutic Use in Clinical Practice
FavorávelMetanálise ClínicaCâncer Doenças Neurodegenerativas Doença de Alzheimer Anandamida (AEA)Tetraidrocanabinol (THC)+16
2022
Cannabis for Medical Use: Versatile Plant Rather Than a Single Drug
FavorávelMetanáliseDor Câncer Inflamação Anandamida (AEA)2-Araquidonoilglicerol (2-AG)+18
2022
Cannabis in Palliative Care: A Systematic Review of Current Evidence
InconclusivoMetanáliseCâncer Insônia e Distúrbios do Sono Náusea e Vômito+6
2022
Cannabis Use and the Endocannabinoid System: A Clinical Perspective
InconclusivoMetanáliseDor Efeitos Adversos da Cannabis Dependência — Cannabis Anandamida (AEA)Tetraidrocanabinol (THC)+19
2022
Cannabis Use in Autism: Reasons for Concern about Risk for Psychosis
InconclusivoMetanálisePsicose Esquizofrenia Epilepsia — Síndrome de Dravet Tetraidrocanabinol (THC)Endocanabinoide (não especificado)+2
2022
Cannabis-based magistral formulation is highly effective as an adjuvant treatment in drug-resistant focal epilepsy in adult patients: an open-label prospective cohort study
FavorávelEnsaio Clínico Duplo-CegoTetraidrocanabinol (THC)
2022
Cannabis-Based Products for the Treatment of Skin Inflammatory Diseases: A Timely Review
FavorávelMetanáliseDor Câncer Inflamação Anandamida (AEA)Tetraidrocanabinol (THC)+28
2022
Current Cannabidiol Safety: A Review
FavorávelMetanáliseDor Câncer Inflamação+10
2022
Cys-loop receptors on cannabinoids: All high?
FavorávelMetanáliseDor Dor — Crônica
2022
Does Cannabidiol Have a Benefit as a Supportive Care Drug in Cancer?
FavorávelMetanáliseDor Câncer Efeitos Adversos da Cannabis Anandamida (AEA)Endocanabinoide (não especificado)+19
2022
E-cigarette vaping associated acute lung injury (EVALI): state of science and future research needs
DesfavorávelMetanáliseCâncer Ansiedade Doenças Cardiovasculares (DCV)+16
2022
Effects of Cannabidiol on Appetite and Body Weight: A Systematic Review
FavorávelMetanáliseAnsiedade Obesidade Diabetes Tetraidrocanabinol (THC)+5
2022
Effects of cannabidiol on simulated driving and cognitive performance: A dose-ranging randomised controlled trial
FavorávelEnsaio Clínico Duplo-CegoEfeitos Adversos da Cannabis Ansiedade Disfunção Cognitiva Tetraidrocanabinol (THC)+1
2022
Effects of Epidiolex® (Cannabidiol) on seizure-related emergency department visits and hospital admissions: A retrospective cohort study
FavorávelMetanáliseCBD Farmacêutico
2022
Effects of short-term environmental stresses on the onset of cannabinoid production in young immature flowers of industrial hemp (Cannabis sativa L.)
FavorávelEstudo LaboratorialCâncer Doença de Parkinson Epilepsia — Síndrome de Dravet Canabigerol (CBG)Canabinol (CBN)+4
2022
Efficacy and safety of adjunctive antiseizure medications for dravet syndrome: A systematic review and network meta-analysis
FavorávelMetanálise ClínicaEpilepsia — Síndrome de Dravet
2022
Efficacy and safety of antiseizure medication for Lennox-Gastaut syndrome: a systematic review and network meta-analysis
FavorávelMetanálise ClínicaEpilepsia — Lennox-Gastaut
2022
Efficacy and safety of cannabidivarin treatment of epilepsy in girls with Rett syndrome: A phase 1 clinical trial
FavorávelEnsaio ClínicoSíndrome de Rett Canabidivarina (CBDV)
2022
Efficiency of Inhaled Cannabidiol in Cannabis Use Disorder: The Pilot Study Cannavap
FavorávelMetanáliseDependência Química Câncer Inflamação THC Farmacêutico THC:CBD Farmacêutico+11
2022
Endothelial dysfunction and angiogenesis: what is missing from COVID-19 and cannabidiol story?
FavorávelMetanáliseInflamação Esclerose Múltipla Epilepsia — Síndrome de Dravet Tetraidrocanabinol (THC)Endocanabinoide (não especificado)+7
2022
Epilepsy and cannabis: so near, yet so far
DesfavorávelMetanáliseEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2022
Evaluation of the Possible Anticonvulsant Effect of Δ 9-Tetrahydrocannabinolic Acid in Murine Seizure Models
InconclusivoEstudo em AnimaisÁcido Tetraidrocanabinólico (THC-a)
2022
Geraniol enhances inhibitory inputs to the paraventricular thalamic nucleus and induces sedation in mice
FavorávelEstudo em AnimaisInsônia e Distúrbios do Sono
2022
Herbal Approaches to Pediatric Functional Abdominal Pain
InconclusivoMetanáliseDor Inflamação Dor — Crônica THC Farmacêutico+10
2022
Impact of Antiseizure Medications on Appetite and Weight in Children
InconclusivoMetanálise ClínicaPerda de Apetite
2022
In vitro evaluation of the interaction of the cannabis constituents cannabichromene and cannabichromenic acid with ABCG2 and ABCB1 transporters
FavorávelEstudo LaboratorialCâncer Inflamação Depressão Canabicromeno (CBC)Ácido Canabicromênico (CBC-a)+1
2022
Interacting binding insights and conformational consequences of the differential activity of cannabidiol with two endocannabinoid-activated G-protein-coupled receptors
FavorávelMetanáliseDoença de Alzheimer Doença de Parkinson Canabinoides Sintéticos AM-x
2022
Long-term use of cannabidiol-enriched medical cannabis in a prospective cohort of children with drug-resistant developmental and epileptic encephalopathy
FavorávelEnsaio ClínicoEncefalite e Mielite
2022
Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indications
FavorávelMetanálise ClínicaDependência — Cannabis Ansiedade Depressão Tetraidrocanabinol (THC)THC Farmacêutico+17
2022
Modulation of Recombinant Human T-Type Calcium Channels by Δ 9-Tetrahydrocannabinolic Acid In Vitro
FavorávelEstudo LaboratorialDor Doenças Neurodegenerativas Ácido Tetraidrocanabinólico (THC-a)
2022
Movement Disorders Secondary to Novel Antiseizure Medications in Pediatric Populations: A Systematic Review and Meta-analysis of Risk
InconclusivoMetanálise ClínicaEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2022
Neuroplastic alterations in cannabinoid receptors type 1 (CB1) in animal models of epileptic seizures
FavorávelMetanáliseEndocanabinoide (não especificado)
2022
Neuroprotection of Cannabidiol, Its Synthetic Derivatives and Combination Preparations against Microglia-Mediated Neuroinflammation in Neurological Disorders
FavorávelMetanáliseDor Inflamação Psicose Canabinoide Sintético (não especificado)Canabidiol Anormal (Abn-CBD)+6
2022
Observational study of medical marijuana as a treatment for treatment-resistant epilepsies
InconclusivoMetanáliseEpilepsia — Lennox-Gastaut Tetraidrocanabinol (THC)
2022
Olivetolic acid, a cannabinoid precursor in Cannabis sativa, but not CBGA methyl ester exhibits a modest anticonvulsant effect in a mouse model of Dravet syndrome
FavorávelEstudo em AnimaisEpilepsia — Síndrome de Dravet Ácido Canabigerólico (CBG-a)
2022
Pain response to cannabidiol in opioid-induced hyperalgesia, acute nociceptive pain, and allodynia using a model mimicking acute pain in healthy adults in a randomized trial (CANAB II)
DesfavorávelEnsaio Clínico Duplo-CegoDor Inflamação Dependência — Opioides CBD Farmacêutico
2022
Persistent Diarrhea and Eosinophilic Esophagitis Resulting From Chronic Cannabidiol Usage for Refractory Epilepsy
DesfavorávelMetanáliseDor Epilepsia — Síndrome de Dravet DII — Doença Inflamatória Intestinal+3
2022
Pharmacokinetics of cannabichromene in a medical cannabis product also containing cannabidiol and Δ9-tetrahydrocannabinol: a pilot study
FavorávelEnsaio Clínico Duplo-CegoDor Inflamação Depressão Tetraidrocanabinol (THC)Monoacilglicerol Lipase (MAGL)+2
2022
Pharmacological effects of cannabidiol by transient receptor potential channels
FavorávelMetanáliseDor Câncer Inflamação+5
2022
Potency and Therapeutic THC and CBD Ratios: U.S. Cannabis Markets Overshoot
DesfavorávelMetanáliseDor Inflamação Efeitos Adversos da Cannabis Tetraidrocanabinol (THC)+4
2022
Practical Considerations for the Use of Cannabis in Cancer Pain Management—What a Medical Oncologist Should Know
FavorávelMetanáliseDor Câncer Dependência — Opioides Anandamida (AEA)2-Araquidonoilglicerol (2-AG)+14
2022
Prescription cannabidiol for seizure disorder management: Initial drug-drug interaction management by specialty pharmacists
FavorávelMetanáliseEfeitos Adversos da Cannabis Epilepsia — Lennox-Gastaut CBD Farmacêutico
2022
Protective Effects of Cannabidiol on Chemotherapy-Induced Oral Mucositis via the Nrf2/Keap1/ARE Signaling Pathways
FavorávelEstudo em AnimaisCâncer Inflamação Doenças Cardiovasculares (DCV)+6
2022
Quantitative electroencephalographic analysis as a potential biomarker of response to treatment with cannabidiol
FavorávelEnsaio ClínicoEfeitos Adversos da Cannabis Doenças Cardiovasculares (DCV)Arritmias Cardíacas CBD Farmacêutico
2022
Recreational cannabis legalizations associated with reductions in prescription drug utilization among Medicaid enrollees
FavorávelMetanáliseDor Ansiedade Dor — Crônica+3
2022
Serum Cannabinoid 24 h and 1 Week Steady State Pharmacokinetic Assessment in Cats Using a CBD/CBDA Rich Hemp Paste
InconclusivoEstudo em AnimaisDor Câncer Ansiedade Tetraidrocanabinol (THC)Ácido Canabidiólico (CBD-a)+3
2022
Shifting the Paradigm on Cannabis Safety
DesfavorávelMetanáliseCâncer Inflamação Efeitos Adversos da Cannabis CBD Farmacêutico+16
2022
Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Ayahuasca Use in a Satanic Ritual: A Case Report
DesfavorávelMetanáliseDoenças Cardiovasculares (DCV)Psicose Dependência — Opioides Ayahuasca+6
2022
Terpene-Enriched CBD oil for treating autism-derived symptoms unresponsive to pure CBD: Case report
FavorávelMetanáliseInflamação Ansiedade Depressão Anandamida (AEA)Hidrolase de Amidas de Ácidos Graxos (FAAH)+5
2022
The Cannabis-Induced Epigenetic Regulation of Genes Associated with Major Depressive Disorder
FavorávelMetanáliseDepressão Psicose Estresse Oxidativo Endocanabinoide (não especificado)+2
2022
The effect of medical cannabis on cognitive functions: a systematic review
DesfavorávelMetanálise ClínicaDor Câncer Efeitos Adversos da Cannabis THC:CBD Farmacêutico CBD Farmacêutico+11
2022
The Effectiveness and Safety of Cannabidiol in Non-seizure-related Indications: A Systematic Review of Published Randomized Clinical Trials
InconclusivoMetanálise ClínicaDependência Química Ansiedade Psicose Tetraidrocanabinol (THC)CBD Farmacêutico+1
2022
The Long-Term Effectiveness and Safety of Cannabidiol-Enriched Oil in Children With Drug-Resistant Epilepsy
FavorávelMetanálise
2022
The Medicinal Natural Products of Cannabis sativa Linn.: A Review
FavorávelMetanáliseCâncer Inflamação Ansiedade Canabinoide Sintético (não especificado)THC Farmacêutico+26
2022
The Potential Proconvulsant Effects of Cannabis: a Scoping Review
DesfavorávelMetanáliseEfeitos Adversos da Cannabis Tetraidrocanabinol (THC)
2022
The Role of the Possible Receptors and Intracellular Pathways in Protective Effect of Exogenous Anandamide in Kindling Model of Epilepsy
FavorávelEstudo em AnimaisAnandamida (AEA)
2022
Therapeutic Potential of Cannabis, Cannabidiol, and Cannabinoid-Based Pharmaceuticals
FavorávelMetanáliseDor Dependência — Cannabis Dor — Crônica THC Farmacêutico THC:CBD Farmacêutico+9
2022
Time to Onset of Cannabidiol (CBD) Treatment Effect and Resolution of Adverse Events in Tuberous Sclerosis Complex: Post Hoc Analysis of Randomized Controlled Phase 3 Trial GWPCARE6
InconclusivoMetanálise
2022
Treatment of Ovarian Hyperstimulation Syndrome in a Mouse Model by Cannabidiol, an Angiogenesis Pathway Inhibitor
FavorávelEstudo em AnimaisDor Câncer Inflamação+16
2022
TRPV1: A Common Denominator Mediating Antinociceptive and Antiemetic Effects of Cannabinoids
FavorávelMetanáliseDor Inflamação Efeitos Adversos da Cannabis Anandamida (AEA)Endocanabinoide (não especificado)+18
2022
Use of cannabidiol in the treatment of epilepsy
FavorávelMetanálise
2022
Use of cannabidiol in the treatment of epilepsy: Lennox-Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex
FavorávelMetanálise ClínicaEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2022
Use of cannabis in the treatment of animals: a systematic review of randomized clinical trials
FavorávelMetanálise ClínicaDor Dor — Crônica Transtornos de Comportamento+3
2021
A 3-year-old child with multi-drug resistant epilepsy responding to pharmacological and nonpharmacological treatments
FavorávelMetanálise
2021
A Mapping Literature Review of Medical Cannabis Clinical Outcomes and Quality of Evidence in Approved Conditions in the USA from 2016 to 2019
InconclusivoMetanáliseDor Câncer Dor — Crônica THC Farmacêutico CBD Farmacêutico+9
2021
A Phase 1 Open-Label, Fixed-Sequence Pharmacokinetic Drug Interaction Trial to Investigate the Effect of Cannabidiol on the CYP1A2 Probe Caffeine in Healthy Subjects
DesfavorávelEnsaio ClínicoEpilepsia — Lennox-Gastaut CBD Farmacêutico
2021
A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures
InconclusivoEnsaio Clínico Duplo-CegoCanabidivarina (CBDV)
2021
A Review of Hemp as Food and Nutritional Supplement
FavorávelMetanáliseAnsiedade Estresse Oxidativo Síndrome Metabólica+2
2021
A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)
FavorávelMetanáliseInflamação Infecções Bacterianas
2021
A validated method for the simultaneous quantification of cannabidiol, Δ9 -tetrahydrocannabinol, and their metabolites in human plasma and application to plasma samples from an oral cannabidiol open-label trial
FavorávelEstudo LaboratorialAnsiedade Dor — Crônica Canabicromeno (CBC)
2021
Add-on cannabidiol in patients with Dravet syndrome: Results of a long-term open-label extension trial
FavorávelEnsaio ClínicoEpilepsia — Síndrome de Dravet
2021
Add-on Cannabidiol Treatment for Drug-Resistant Seizures in Tuberous Sclerosis Complex
FavorávelEnsaio Clínico Duplo-CegoCBD Farmacêutico
2021
Allosteric modulation of the cannabinoid 2 receptor confers seizure resistance in mice
FavorávelEstudo em AnimaisCanabinoide Sintético (não especificado)
2021
An Evaluation of Understudied Phytocannabinoids and Their Effects in Two Neuronal Models
InconclusivoEstudo LaboratorialEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut 2-Araquidonoilglicerol (2-AG)Canabicromeno (CBC)+2
2021
Anti-seizure medications for Lennox-Gastaut syndrome
InconclusivoMetanáliseEpilepsia — Lennox-Gastaut CBD Farmacêutico
2021
Anticonvulsant activity of β-caryophyllene in association with pregabalin in a seizure model in rats
FavorávelEstudo em Animais
2021
Anticonvulsant, Anxiolytic and Antidepressant Properties of the β-caryophyllene in Swiss Mice: Involvement of Benzodiazepine-GABAAergic, Serotonergic and Nitrergic Systems
FavorávelEstudo em AnimaisAnsiedade Depressão
2021
Cannabichromene, Related Phytocannabinoids, and 5-Fluoro-cannabichromene Have Anticonvulsant Properties in a Mouse Model of Dravet Syndrome
FavorávelEstudo em AnimaisEpilepsia — Síndrome de Dravet Canabicromeno (CBC)Ácido Canabicromênico (CBC-a)
2021
Cannabidiol (CBD) Alters the Functionality of Neutrophils (PMN). Implications in the Refractory Epilepsy Treatment
DesfavorávelEstudo LaboratorialInflamação Estresse Oxidativo
2021
Cannabidiol (CBD) and cognition in epilepsy
FavorávelMetanálise
2021
Cannabidiol and Abnormal Liver Chemistries in Healthy Adults: Results of a Phase I Clinical Trial
FavorávelMetanáliseEfeitos Adversos da Cannabis Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico+1
2021
Cannabidiol and mental health: possibilities, uncertainties, and controversies for addiction treatment
InconclusivoMetanáliseDependência Química Ansiedade Depressão+10
2021
Cannabidiol and Neurodevelopmental Disorders in Children
FavorávelMetanáliseInflamação Ansiedade Depressão Anandamida (AEA)2-Araquidonoilglicerol (2-AG)+17
2021
Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications
FavorávelMetanáliseEpilepsia — Síndrome de Dravet
2021
Cannabidiol for the treatment of Lennox-Gastaut syndrome and Dravet syndrome: experts' recommendations for its use in clinical practice in Spain
FavorávelMetanáliseEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2021
Cannabidiol in conjunction with clobazam: analysis of four randomized controlled trials
FavorávelEnsaio Clínico Duplo-CegoCBD Farmacêutico
2021
Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action
FavorávelMetanáliseCâncer Doenças Neurodegenerativas Esclerose Múltipla+1
2021
Cannabidiol in Pharmacoresistant Epilepsy: Clinical Pharmacokinetic Data From an Expanded Access Program
FavorávelEnsaio ClínicoEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2021
Cannabidiol in the Treatment of Epilepsy
FavorávelMetanáliseEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2021
Cannabidiol in the treatment of epilepsy: Current evidence and perspectives for further research
FavorávelMetanálise
2021
Cannabidiol Interactions with Medications, Illicit Substances, and Alcohol: a Comprehensive Review
DesfavorávelMetanáliseDepressão Dependência — Opioides Dependência — Álcool CBD Farmacêutico+3
2021
Cannabidiol modifies the seizure expression and effects of antiseizure drugs in a rat model of recurrent severe seizures
FavorávelEstudo em Animais
2021
Cannabidiol reduces soman-induced lethality and seizure severity in female plasma carboxylesterase knockout mice treated with midazolam
FavorávelEstudo em Animais
2021
Cannabidiol Therapy for Refractory Epilepsy and Seizure Disorders
FavorávelMetanálise
2021
Cannabidiol treatment of severe refractory epilepsy in children and young adults
FavorávelMetanáliseEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2021
Cannabidiol-enriched medical cannabis as add-on therapy in children with treatment-resistant West syndrome: A study of eight patients
FavorávelEnsaio Clínico
2021
Cannabidiol-enriched oil in children and adults with treatment-resistant epilepsy-does tolerance exist?
DesfavorávelMetanálise
2021
Cannabidiol: pharmacology and therapeutic targets
FavorávelMetanáliseDor Inflamação Dor — Crônica+4
2021
Cannabidiolic acid exhibits entourage-like improvements of anticonvulsant activity in an acute rat model of seizures
FavorávelEstudo em AnimaisÁcido Canabidiólico (CBD-a)
2021
Cannabigerolic acid, a major biosynthetic precursor molecule in cannabis, exhibits divergent effects on seizures in mouse models of epilepsy
FavorávelEstudo em AnimaisEpilepsia — Síndrome de Dravet Ácido Canabigerólico (CBG-a)
2021
Cannabinoid control of hippocampal functions: the where matters
FavorávelMetanáliseInflamação Disfunção Cognitiva Psicose Anandamida (AEA)Endocanabinoide (não especificado)+6
2021
Cannabinoid hyperemesis syndrome can be relieved by warm baths
DesfavorávelMetanáliseDor Efeitos Adversos da Cannabis Dependência — Cannabis+2
2021
Cannabinoids in Audiogenic Seizures: From Neuronal Networks to Future Perspectives for Epilepsy Treatment
FavorávelMetanáliseEndocanabinoide (não especificado)
2021
Cannabis Use among Cancer Survivors amid the COVID-19 Pandemic: Results from the COVID-19 Cannabis Health Study
InconclusivoEnsaio ClínicoCâncer Insônia e Distúrbios do Sono Náusea e Vômito+3
2021
Case Report: Lennox-Gastaut Epileptic Encephalopathy Responsive to Cannabidiol Treatment Associated With a Novel de novo Mosaic SHANK1 Variant
FavorávelMetanáliseEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut Autismo
2021
Chronic cannabidiol (CBD) administration induces anticonvulsant and antiepileptogenic effects in a genetic model of epilepsy
FavorávelEstudo em Animais
2021
Cognitive and behavioral effects of cannabidiol in patients with treatment-resistant epilepsy
FavorávelEnsaio Clínico
2021
Combined Antiseizure Efficacy of Cannabidiol and Clonazepam in a Conditional Mouse Model of Dravet Syndrome
FavorávelEstudo em AnimaisEpilepsia — Síndrome de Dravet
2021
Contribution of the Adenosine 2A Receptor to Behavioral Effects of Tetrahydrocannabinol, Cannabidiol and PECS-101
DesfavorávelEstudo em AnimaisDor Inflamação Efeitos Adversos da Cannabis+5
2021
Cost-Effectiveness of Medicinal Cannabis for Management of Refractory Symptoms Associated With Chronic Conditions: A Systematic Review of Economic Evaluations
FavorávelMetanáliseDor Dor — Crônica Esclerose Múltipla THC Farmacêutico THC:CBD Farmacêutico+7
2021
Cross-sectional and longitudinal evaluation of cannabidiol (CBD) product use and health among people with epilepsy
FavorávelMetanálise
2021
Current controversies in medical cannabis: Recent developments in human clinical applications and potential therapeutics
InconclusivoMetanáliseAnsiedade Esclerose Múltipla TEPT
2021
Current review of hemp-based medicines in dogs
FavorávelMetanáliseArtrite Aplicações Veterinárias Artrite — Osteoartrite
2021
Cytochrome P450-Catalyzed Metabolism of Cannabidiol to the Active Metabolite 7-Hydroxy-Cannabidiol
DesfavorávelEstudo LaboratorialEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut Hepatite CBD Farmacêutico+1
2021
Development of central precocious puberty following cannabinoid use for paediatric epilepsy: causal or coincidence?
FavorávelMetanálise
2021
Dravet syndrome
FavorávelMetanáliseEpilepsia — Síndrome de Dravet
2021
Effect of Cannabidiol on Interictal Epileptiform Activity and Sleep Architecture in Children with Intractable Epilepsy: A Prospective Open-Label Study
FavorávelEnsaio ClínicoEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2021
Efficacy and safety of medical cannabinoids in children: a systematic review and meta-analysis
FavorávelMetanáliseEfeitos Adversos da Cannabis Epilepsia — Síndrome de Dravet Perda de Apetite THC Farmacêutico THC:CBD Farmacêutico+2
2021
Efficacy and safety of paediatric medicinal cannabis use: A scoping review
DesfavorávelMetanáliseDor Câncer Transtornos de Comportamento THC Farmacêutico CBD Farmacêutico+6
2021
Efficacy of Phytocannabinoids in Epilepsy Treatment: Novel Approaches and Recent Advances
InconclusivoMetanáliseCanabigerol (CBG)Canabidivarina (CBDV)
2021
Endocannabinoid-serotonin systems interaction in health and disease
FavorávelMetanáliseAnsiedade Depressão Psicose Endocanabinoide (não especificado)
2021
Epileptic Phenotype and Cannabidiol Efficacy in a Williams–Beuren Syndrome Patient With Atypical Deletion: A Case Report
FavorávelMetanáliseEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2021
Evidence for an increase in cannabis use in Iran - A systematic review and trend analysis
DesfavorávelMetanáliseDependência Química Efeitos Adversos da Cannabis Dependência — Cannabis
2021
Exacerbation of eyelid myoclonia in patients with epilepsy and eyelid myoclonia receiving cannabidiol
DesfavorávelMetanálise
2021
Exploiting cannabinoid and vanilloid mechanisms for epilepsy treatment
InconclusivoMetanáliseAnandamida (AEA)
2021
From an Alternative Medicine to a New Treatment for Refractory Epilepsies: Can Cannabidiol Follow the Same Path to Treat Neuropsychiatric Disorders?
FavorávelMetanálise
2021
Functional Connectivity Derived From Electroencephalogram in Pharmacoresistant Epileptic Encephalopathy Using Cannabidiol as Adjunctive Antiepileptic Therapy
FavorávelEnsaio ClínicoTHC:CBD Farmacêutico
2021
Highly Purified Cannabidiol for Epilepsy Treatment: A Systematic Review of Epileptic Conditions Beyond Dravet Syndrome and Lennox-Gastaut Syndrome
FavorávelMetanálise ClínicaEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2021
Improved Bioavailability with Dry Powder Cannabidiol Inhalation: A Phase 1 Clinical Study
FavorávelEnsaio ClínicoDor Ansiedade Dor — Crônica CBD Farmacêutico+3
2021
Interaction of cannabidiol with other antiseizure medications: A narrative review
FavorávelMetanálise
2021
Lethal case of myocardial ischemia following overdose of the synthetic cannabinoid ADB-FUBINACA
DesfavorávelMetanáliseInflamação Efeitos Adversos da Cannabis Doenças Cardiovasculares (DCV)Canabinoide Sintético (não especificado)+12
2021
Long-term cannabidiol treatment for seizures in patients with tuberous sclerosis complex: An open-label extension trial
FavorávelEnsaio ClínicoEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2021
Long-term safety and efficacy of add-on cannabidiol in patients with Lennox-Gastaut syndrome: Results of a long-term open-label extension trial
FavorávelEnsaio Clínico Duplo-CegoEpilepsia — Lennox-Gastaut CBD Farmacêutico
2021
Long-term safety and efficacy of highly purified cannabidiol for treatment refractory epilepsy
FavorávelEnsaio ClínicoCBD Farmacêutico
2021
Longitudinal impact of cannabidiol on EEG measures in subjects with treatment-resistant epilepsy
FavorávelEnsaio ClínicoCBD Farmacêutico
2021
Medical cannabis for severe treatment resistant epilepsy in children: a case-series of 10 patients
FavorávelEnsaio Clínico
2021
Medicinal applications of cannabis/cannabinoids
InconclusivoMetanáliseDor Insônia e Distúrbios do Sono CBD Farmacêutico
2021
Mixed methods study of the potential therapeutic benefits from medical cannabis for patients in Florida
FavorávelMetanáliseDor Dor — Crônica Depressão+6
2021
Myrcene—What Are the Potential Health Benefits of This Flavouring and Aroma Agent?
FavorávelMetanáliseDor Câncer Inflamação Endocanabinoide (não especificado)+9
2021
Natural and Synthetic Cannabinoids: Pharmacology, Uses, Adverse Drug Events, and Drug Interactions
DesfavorávelMetanáliseDor Dependência Química Efeitos Adversos da Cannabis 2-Araquidonoilglicerol (2-AG)Canabinoide Sintético (não especificado)+24
2021
Neuroprotective Potential of Limonene and Limonene Containing Natural Products
FavorávelMetanáliseAnsiedade Doenças Neurodegenerativas Esclerose Múltipla+2
2021
New therapeutic approach in Dravet syndrome and Lennox-Gastaut syndrome with cannabidiol
FavorávelMetanáliseEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2021
Perspectives of pediatric oncologists and palliative care physicians on the therapeutic use of cannabis in children with cancer
FavorávelMetanáliseDor Câncer Dor — Crônica+7
2021
Pharmacokinetics of cannabidiol in children with refractory epileptic encephalopathy
InconclusivoEnsaio ClínicoEncefalite e Mielite
2021
Polypharmacological Approaches for CNS Diseases: Focus on Endocannabinoid Degradation Inhibition
FavorávelMetanáliseDor Inflamação Dor — Crônica Anandamida (AEA)Endocanabinoide (não especificado)+14
2021
Potential Benefit of Add-on Δ9-Tetrahydrocannabinol in Pediatric Drug-Resistant Epilepsy: A Case Series
FavorávelMetanálise
2021
Potential therapeutic uses of cannabinoids to treat behavioural problems in children and adolescents with developmental disorders
FavorávelMetanáliseEfeitos Adversos da Cannabis Ansiedade Depressão+8
2021
Preclinical investigation of β-caryophyllene as a therapeutic agent in an experimental murine model of Dravet syndrome
FavorávelEstudo em AnimaisEpilepsia — Síndrome de Dravet
2021
Results From an Italian Expanded Access Program on Cannabidiol Treatment in Highly Refractory Dravet Syndrome and Lennox–Gastaut Syndrome
FavorávelEnsaio ClínicoEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2021
Safety and tolerability of escalating cannabinoid doses in healthy cats
FavorávelEstudo em AnimaisDor Efeitos Adversos da Cannabis Dor — Crônica Ácido Canabidiólico (CBD-a)+3
2021
Safety and Tolerability of Transdermal Cannabidiol Gel in Children With Developmental and Epileptic Encephalopathies: A Nonrandomized Controlled Trial
FavorávelEnsaio ClínicoEncefalite e Mielite
2021
Seizure and Interictal Electroencephalographic (EEG) Changes with Cannabinoid Concentrate Use
DesfavorávelMetanálise
2021
Seizure frequency, quality of life, behavior, cognition, and sleep in pediatric patients enrolled in a prospective, open-label clinical study with cannabidiol
FavorávelEnsaio ClínicoInsônia e Distúrbios do Sono Transtornos de Comportamento CBD Farmacêutico
2021
The (Poly)Pharmacology of Cannabidiol in Neurological and Neuropsychiatric Disorders: Molecular Mechanisms and Targets
FavorávelMetanáliseAnsiedade Esquizofrenia
2021
The long-term efficacy of cannabidiol in the treatment of refractory epilepsy
FavorávelMetanáliseCBD Farmacêutico
2021
The perceived effects of cannabis products in the management of seizures in CDKL5 Deficiency Disorder
FavorávelEnsaio Clínico
2021
Therapeutic potential of cannabidivarin for epilepsy and autism spectrum disorder
InconclusivoMetanáliseAutismo Canabidivarina (CBDV)
2021
Time to onset of cannabidiol (CBD) treatment effect in Lennox–Gastaut syndrome: Analysis from two randomized controlled trials
FavorávelMetanálise ClínicaEpilepsia — Lennox-Gastaut CBD Farmacêutico
2021
Time to onset of cannabidiol treatment effects in Dravet syndrome: Analysis from two randomized controlled trials
FavorávelMetanálise ClínicaEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2021
Treatment Guidelines for Rare, Early-Onset, Treatment-Resistant Epileptic Conditions: A Literature Review on Dravet Syndrome, Lennox-Gastaut Syndrome and CDKL5 Deficiency Disorder
InconclusivoMetanálise ClínicaEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2021
Two-center experience of cannabidiol use in adults with Dravet syndrome
FavorávelEnsaio ClínicoEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut Qualidade de Vida CBD Farmacêutico
2021
UHPLC-MS/MS Analysis of Cannabidiol and Its Metabolites in Serum of Patients with Resistant Epilepsy Treated with CBD Formulations
InconclusivoEstudo LaboratorialCBD Farmacêutico
2021
Use and caregiver-reported efficacy of medical cannabis in children and adolescents in Switzerland
FavorávelMetanáliseDor Náusea e Vômito Anorexia (perda de apetite)Canabinoide Sintético (não especificado)
2021
White matter integrity after cannabidiol administration for treatment resistant epilepsy
FavorávelEnsaio ClínicoCBD Farmacêutico
2021
Δ9-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats
FavorávelEstudo em AnimaisTetraidrocanabivarina (THCV)
2020
A perspective on cannabinoids for treating epilepsy: Do they really change the landscape?
FavorávelMetanálise
2020
A Phase 1, Randomised, Placebo-Controlled, Dose Escalation Study to Investigate the Safety, Tolerability and Pharmacokinetics of Cannabidiol in Fed Healthy Volunteers
FavorávelEnsaio Clínico Duplo-CegoInflamação Ansiedade Náusea e Vômito
2020
A Phase 2, Double-Blind, Placebo-Controlled Trial to Investigate Potential Drug-Drug Interactions Between Cannabidiol and Clobazam
FavorávelEnsaio Clínico Duplo-CegoEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2020
A Phase I, Open-Label, Parallel-Group, Single-Dose Trial of the Pharmacokinetics, Safety, and Tolerability of Cannabidiol in Subjects with Mild to Severe Renal Impairment
FavorávelEnsaio ClínicoEfeitos Adversos da Cannabis Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico+1
2020
A Phase II Randomized Trial to Explore the Potential for Pharmacokinetic Drug-Drug Interactions with Stiripentol or Valproate when Combined with Cannabidiol in Patients with Epilepsy
FavorávelEnsaio Clínico Duplo-CegoEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2020
A systematic review of minor phytocannabinoids with promising neuroprotective potential
FavorávelMetanáliseDoenças Neurodegenerativas Doença de Alzheimer Doença de Parkinson Tetraidrocanabinol (THC)Canabigerol (CBG)+2
2020
Adjunctive Cannabidiol in Patients with Dravet Syndrome: A Systematic Review and Meta-Analysis of Efficacy and Safety
FavorávelMetanálise ClínicaEpilepsia — Síndrome de Dravet
2020
Anandamide Metabolites Protect against Seizures through the TRP Channel Water Witch in Drosophila melanogaster
FavorávelEstudo em AnimaisAnandamida (AEA)2-Araquidonoilglicerol (2-AG)
2020
Anticonvulsive Properties of Cannabidiol in a Model of Generalized Seizure Are Transient Receptor Potential Vanilloid 1 Dependent
FavorávelEstudo em Animais
2020
Barriers in accessing medical cannabis for children with drug-resistant epilepsy in Canada: A qualitative study
FavorávelMetanálise
2020
Behavioral and Molecular Effects Induced by Cannabidiol and Valproate Administration in the GASH/Sal Model of Acute Audiogenic Seizures
InconclusivoEstudo em AnimaisAnandamida (AEA)
2020
Cannabidiol (CBD)
FavorávelMetanáliseInflamação Ansiedade Doenças Neurodegenerativas+4
2020
Cannabidiol (CBD) Inhibited Rhodamine-123 Efflux in Cultured Vascular Endothelial Cells and Astrocytes Under Hypoxic Conditions
FavorávelEstudo LaboratorialEstresse Oxidativo
2020
Cannabidiol anticonvulsant effect is mediated by the PI3Kγ pathway
FavorávelEstudo em Animais
2020
Cannabidiol disrupts conditioned fear expression and cannabidiolic acid reduces trauma-induced anxiety-related behaviour in mice
FavorávelEstudo em AnimaisDor Ansiedade Náusea e Vômito Ácido Canabidiólico (CBD-a)
2020
Cannabidiol Drugs Clinical Trial Outcomes and Adverse Effects
FavorávelMetanálise ClínicaDependência — Cannabis Dependência — Opioides Esquizofrenia CBD Farmacêutico+2
2020
Cannabidiol efficacy independent of clobazam: Meta-analysis of four randomized controlled trials
FavorávelMetanálise ClínicaEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2020
Cannabidiol for epilepsy (Lennox-Gastaut syndrome, Dravet syndrome)
FavorávelMetanálise ClínicaEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2020
Cannabidiol inhibits febrile seizure by modulating AMPA receptor kinetics through its interaction with the N-terminal domain of GluA1/GluA2
FavorávelEstudo em AnimaisEpilepsia — FIRES
2020
Cannabidiol normalizes resting-state functional connectivity in treatment-resistant epilepsy
FavorávelEnsaio ClínicoCBD Farmacêutico
2020
Cannabidiol or CBD Oil: Help, Hope, and Hype for Psychiatric and Neurologic Conditions
FavorávelMetanáliseTetraidrocanabinol (THC)
2020
Cannabinoids in the Treatment of Epilepsy: Current Status and Future Prospects
FavorávelMetanálise
2020
Cannabinoids Rescue Cocaine-Induced Seizures by Restoring Brain Glycine Receptor Dysfunction
FavorávelEstudo em AnimaisDependência Química Dependência — Cocaína
2020
Cannabinoids: A New Perspective on Epileptogenesis and Seizure Treatment in Early Life in Basic and Clinical Studies
FavorávelMetanálise
2020
Cannabis constituents reduce seizure behavior in chemically-induced and scn1a-mutant zebrafish
FavorávelEstudo em AnimaisCanabinol (CBN)
2020
Cannabis for Pediatric Epilepsy
FavorávelMetanálise
2020
Cannabis sativa: Much more beyond Δ 9-tetrahydrocannabinol
FavorávelMetanáliseDor Dor — Crônica Doenças Neurodegenerativas+1
2020
Cannabis Treatment in Children with Epilepsy: Practices of Canadian Neurologists
FavorávelMetanálise
2020
Cannabis, More Than the Euphoria: Its Therapeutic Use in Drug-Resistant Epilepsy
FavorávelMetanálise
2020
CB2R orchestrates neuronal autophagy through regulation of the mTOR signaling pathway in the hippocampus of developing rats with status epilepticus
FavorávelEstudo em AnimaisCanabinoides Sintéticos AM-x Canabinoides Sintéticos JWH-x
2020
Clinical trial simulations of the interaction between cannabidiol and clobazam and effect on drop-seizure frequency
FavorávelMetanáliseEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2020
Cognitive function and adaptive skills after a one-year trial of cannabidiol (CBD) in a pediatric sample with treatment-resistant epilepsy
FavorávelEnsaio ClínicoDisfunção Cognitiva Transtornos de Comportamento CBD Farmacêutico
2020
Development of cannabidiol as a treatment for severe childhood epilepsies
FavorávelMetanálise
2020
Does cannabidiol have antiseizure activity independent of its interactions with clobazam? An appraisal of the evidence from randomized controlled trials
FavorávelMetanálise ClínicaEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2020
Dose-Ranging Effect of Adjunctive Oral Cannabidiol vs Placebo on Convulsive Seizure Frequency in Dravet Syndrome: A Randomized Clinical Trial
FavorávelEnsaio Clínico Duplo-CegoEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2020
Drug-Drug Interactions Between Cannabidiol and Lithium
FavorávelMetanáliseEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut Autismo+1
2020
Economic Evaluation of Cannabinoid Oil for Dravet Syndrome: A Cost-Utility Analysis
FavorávelMetanáliseEpilepsia — Síndrome de Dravet
2020
Effect of Cannabinoids on Electroencephalography of a Child with Lennox-Gastaut Syndrome
FavorávelMetanáliseEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2020
Efficacy and adverse event profile of cannabidiol and medicinal cannabis for treatment-resistant epilepsy: Systematic review and meta-analysis
FavorávelMetanálise Clínica
2020
Ending the pain of children with severe epilepsy? An audit of the impact of medical cannabis in 10 patients
FavorávelMetanálise
2020
Endocannabinoid System and Cannabinoid 1 Receptors in Patients With Pharmacoresistant Temporal Lobe Epilepsy and Comorbid Mood Disorders
FavorávelMetanáliseAnandamida (AEA)2-Araquidonoilglicerol (2-AG)
2020
Epilepsy and cannabidiol: a guide to treatment
FavorávelMetanálise Clínica
2020
Interactions between cannabidiol and Δ 9 -tetrahydrocannabinol in modulating seizure susceptibility and survival in a mouse model of Dravet syndrome
FavorávelEstudo em AnimaisEpilepsia — Síndrome de Dravet
2020
Inverse Agonism of Cannabinoid Receptor Type 2 Confers Anti-inflammatory and Neuroprotective Effects Following Status Epileptics
FavorávelEstudo em Animais
2020
Lennox–Gastaut Syndrome: Perspective of a Parent and a Physician
FavorávelMetanáliseEpilepsia — Lennox-Gastaut CBD Farmacêutico
2020
Mapping cannabis potency in medical and recreational programs in the United States
DesfavorávelMetanáliseDor Ansiedade Dor — Crônica Tetraidrocanabinol (THC)+4
2020
Molecular Targets of Cannabidiol in Experimental Models of Neurological Disease
FavorávelMetanáliseInflamação Ansiedade Depressão Anandamida (AEA)2-Araquidonoilglicerol (2-AG)+8
2020
Neural Stem Cells and Cannabinoids in the Spotlight as Potential Therapy for Epilepsy
FavorávelMetanáliseAnandamida (AEA)2-Araquidonoilglicerol (2-AG)+2
2020
Overview of cannabidiol (CBD) and its analogues: Structures, biological activities, and neuroprotective mechanisms in epilepsy and Alzheimer's disease
FavorávelMetanáliseDoença de Alzheimer
2020
Pharmacogenetic Predictors of Cannabidiol Response and Tolerability in Treatment-Resistant Epilepsy
FavorávelEnsaio ClínicoEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2020
Phenotype-Based Screening of Synthetic Cannabinoids in a Dravet Syndrome Zebrafish Model
FavorávelEstudo em AnimaisEpilepsia — Síndrome de Dravet Canabinoides Sintéticos JWH-x Canabinoides Sintéticos AB-x
2020
Phytocannabinoids in Neurological Diseases: Could They Restore a Physiological GABAergic Transmission?
InconclusivoMetanáliseAnsiedade Doença de Alzheimer Doença de Parkinson+2
2020
Practical use of pharmaceutically purified oral cannabidiol in Dravet syndrome and Lennox-Gastaut syndrome
FavorávelMetanáliseEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2020
Receptors and Channels Possibly Mediating the Effects of Phytocannabinoids on Seizures and Epilepsy
FavorávelMetanálise
2020
Response to cannabidiol in epilepsy of infancy with migrating focal seizures associated with KCNT1 mutations: An open-label, prospective, interventional study
FavorávelEnsaio Clínico
2020
Synthetic pharmaceutical grade cannabidiol for treatment of refractory infantile spasms: A multicenter phase-2 study
DesfavorávelEnsaio ClínicoCanabinoide Sintético (não especificado)
2020
Terpenes/Terpenoids in Cannabis: Are They Important?
FavorávelMetanáliseDor Câncer Inflamação+10
2020
The anticonvulsant effects of cannabidiol in experimental models of epileptic seizures: From behavior and mechanisms to clinical insights
FavorávelMetanálise
2020
The Endocannabinoid System and Synthetic Cannabinoids in Preclinical Models of Seizure and Epilepsy
FavorávelMetanáliseCanabinoide Sintético (não especificado)Hidrolase de Amidas de Ácidos Graxos (FAAH)+1
2020
The Endocannabinoid System May Modulate Sleep Disorders in Aging
InconclusivoMetanáliseAnsiedade Doenças Cardiovasculares (DCV)Depressão Anandamida (AEA)Endocanabinoide (não especificado)+13
2020
The proposed mechanisms of action of CBD in epilepsy
FavorávelMetanálise
2020
The role of cannabinoids in epilepsy treatment: a critical review of efficacy results from clinical trials
InconclusivoMetanálise Clínica
2020
The Use of Cannabis as a Treatment for Epilepsy in Adult Patients: Are Side Effects a Limitation of Use?
FavorávelMetanálise
2020
The use of medical grade cannabis in Italy for drug-resistant epilepsy: a case series
FavorávelMetanáliseTetraidrocanabinol (THC)
2020
Therapeutic Efficacy of Cannabidiol (CBD): A Review of the Evidence from Clinical Trials and Human Laboratory Studies
InconclusivoMetanáliseDor Dependência Química Inflamação+6
2019
A Comprehensive Review of Cannabis in Patients with Cancer: Availability in the USA, General Efficacy, and Safety
InconclusivoMetanáliseDor Câncer Epilepsia — Lennox-Gastaut CBD Farmacêutico+1
2019
A Phase 1, Open-Label, Pharmacokinetic Trial to Investigate Possible Drug-Drug Interactions Between Clobazam, Stiripentol, or Valproate and Cannabidiol in Healthy Subjects
FavorávelEnsaio ClínicoEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2019
A systematic review of cannabidiol dosing in clinical populations
FavorávelMetanálise ClínicaDor Dependência — Cannabis Ansiedade+14
2019
Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy
FavorávelMetanáliseEstresse Oxidativo
2019
Are there mortality risks for patients with epilepsy who use cannabis treatments as monotherapy?
DesfavorávelMetanáliseEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2019
Can we teach old drugs new tricks?-Repurposing of neuropharmacological drugs for inflammatory skin diseases
FavorávelMetanáliseInflamação Depressão Dependência — Opioides+14
2019
Cannabidiol as adjunctive treatment of seizures associated with Lennox-Gastaut syndrome and Dravet syndrome
InconclusivoMetanáliseEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2019
Cannabidiol in patients with Lennox-Gastaut syndrome: Interim analysis of an open-label extension study
FavorávelEnsaio Clínico Duplo-CegoEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut CBD Farmacêutico
2019
Cannabidiol: A New Hope for Patients With Dravet or Lennox-Gastaut Syndromes
FavorávelMetanáliseEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2019
Cannabidiol: A Review of Clinical Efficacy and Safety in Epilepsy
FavorávelMetanáliseEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2019
Cannabinoid therapy in epilepsy
InconclusivoMetanáliseEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2019
Cannabinoids for drug-resistant seizures in a critically ill patient-Case report and literature review
FavorávelMetanáliseEpilepsia — Lennox-Gastaut
2019
Cannabis and Epilepsy
FavorávelMetanáliseEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2019
Cannabis for refractory epilepsy in children: A review focusing on CDKL5 Deficiency Disorder
FavorávelMetanáliseEpilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
2019
Cannabis Use Disorder and Epilepsy: A Cross-National Analysis of 657 072 Hospitalized Patients
InconclusivoMetanáliseDependência — Cannabis
2019
Cannabis use is both independently associated with and mediates worse psychosocial health in patients with epilepsy
DesfavorávelMetanáliseEfeitos Adversos da Cannabis Depressão
2019
Comparative Study of Alpha- And Beta-Pinene Effect on PTZ-induced Convulsions in Mice
InconclusivoEstudo em Animais
2019
Drug-drug Interaction Studies with Coadministration of Cannabidiol (CBD) and Clobazam, Valproate, Stiripentol or Midazolam in Healthy Volunteers and Adults with Epilepsy
InconclusivoEnsaio Clínico
2019
Food effect on pharmacokinetics of cannabidiol oral capsules in adult patients with refractory epilepsy
InconclusivoMetanálise
2019
Marijuana use among patients with epilepsy at a tertiary care center
InconclusivoMetanálise
2019
Prospective evaluation of oral cannabis extracts in children with epilepsy
InconclusivoEnsaio Clínico
2019
Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials
FavorávelMetanálise Clínica
2018
Cannabidiol Regulates Long Term Potentiation Following Status Epilepticus: Mediation by Calcium Stores and Serotonin.
FavorávelEstudo em Animais
2018
Open-label use of highly purified CBD (Epidiolex®) in patients with CDKL5 deficiency disorder and Aicardi, Dup15q, and Doose syndromes.
FavorávelEnsaio Clínico
2018
Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice.
FavorávelEstudo em Animais
2017
Assessing the role of serotonergic receptors in cannabidiol's anticonvulsant efficacy.
FavorávelEstudo em Animais
2017
Could Cannabidiol be a Treatment Option for Intractable Childhood and Adolescent Epilepsy?
FavorávelMetanálise
2017
Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP)
FavorávelEstudo em Animais
2017
Quality of Life in Childhood Epilepsy in pediatric patients enrolled in a prospective, open-label clinical study with cannabidiol.
FavorávelMetanálise
2017
Report from a Survey of Parents Regarding the Use of Cannabidiol (Medicinal cannabis) in Mexican Children with Refractory Epilepsy
FavorávelMetanálise
2016
Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures.
FavorávelEstudo em Animais
2016
Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex.
FavorávelEnsaio Clínico
2016
Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial.
FavorávelEnsaio Clínico
2016
Cannabidiol Post-Treatment Alleviates Rat Epileptic-Related Behaviors and Activates Hippocampal Cell Autophagy Pathway Along with Antioxidant Defense in Chronic Phase of Pilocarpine-Induced Seizure.
FavorávelEstudo em Animais
2016
CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience
FavorávelMetanálise
2016
From Cannabis to Cannabidiol to Treat Epilepsy, Where Are We?
FavorávelMetanálise
2016
Marijuana use in adults admitted to a Canadian epilepsy monitoring unit.
FavorávelMetanálise
2016
Plant-Derived and Endogenous Cannabinoids in Epilepsy.
FavorávelMetanálise
2016
The Pharmacological Basis of Cannabis Therapy for Epilepsy.
FavorávelMetanálise
2016
Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol.
FavorávelMetanáliseTetraidrocanabinol (THC)
2015
Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy.
FavorávelMetanáliseEndocanabinoide (não especificado)
2012
Cannabinoids for epilepsy
InconclusivoMetanálise Clínica
2010
Anticonvulsant and anxiolytic evaluation of leaf extracts of Ocimum gratissimum, a culinary herb
FavorávelEstudo em AnimaisAnsiedade
2010
Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy.
FavorávelEnsaio ClínicoAnandamida (AEA)2-Araquidonoilglicerol (2-AG)
2006
Evolution of the Anticonvulsant Activity of α-Terpineol
FavorávelEstudo em Animais
2003
International Association for Cannabis as Medicine.
FavorávelMetanálise
1995
Effects of Linalool on glutamatergic system in the rat cerebral cortex.
FavorávelEstudo em AnimaisAnsiedade
1980
Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients.
FavorávelEnsaio Clínico Duplo-Cego

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Canabinoides e compostos

CBD Farmacêutico 94 Tetraidrocanabinol (THC) 44 Anandamida (AEA) 41 2-Araquidonoilglicerol (2-AG) 30 Endocanabinoide (não especificado) 29 THC Farmacêutico 29 THC:CBD Farmacêutico 28 Hidrolase de Amidas de Ácidos Graxos (FAAH) 26

Sistemas do corpo

Sistema Nervoso 239 Saúde Mental e Emocional 40 Sistema Imunológico 21 Sistema Digestório 9 Sistema Reprodutor 4 Sistema Endócrino 3

Perguntas frequentes

Quantos estudos sobre epilepsia estão indexados no acervo?

São 460 estudos, publicados entre 1839 e 2024. O acervo inteiro tem 7.640 registros.

Que tipos de estudo predominam?

Metanálise: 235 · Estudo em Animais: 84 · Ensaio Clínico: 62 · Metanálise Clínica: 36 · Ensaio Clínico Duplo-Cego: 23 · Estudo Laboratorial: 20. A classificação segue o desenho declarado na fonte.

O que significa a classificação de resultado?

É uma leitura automatizada da conclusão de cada estudo, em três direções — favorável, inconclusivo e desfavorável. Aqui são 368 favoráveis, 54 inconclusivos e 38 desfavoráveis. Serve para navegar o acervo, não para concluir nada clinicamente: a conclusão válida é a do artigo original.

Como citar esta página

ABNT

CANNABIS INDICA. Epilepsia — estudos científicos sobre cannabis. 2026. Disponível em: https://cannabisindica.com.br/condicao/epilepsia/. Acesso em: 13 set. 2026.

APA

Cannabis Indica. (2026). Epilepsia — estudos científicos sobre cannabis. https://cannabisindica.com.br/condicao/epilepsia/

Esta página é um índice de acesso. Ao usar um estudo como evidência, cite o artigo original — o link de cada registro leva à fonte.