cannabis indica

Canabicromeno (CBC)

termo de indexação original: Cannabichromene (CBC)

O que é Canabicromeno (CBC)

O canabicromeno, ou CBC, é um fitocanabinoide não psicoativo e, em várias variedades, o terceiro composto mais abundante da planta, atrás apenas de THC e CBD. Apesar disso, foi por muito tempo o menos estudado dos canabinoides principais.

Sua farmacologia é atípica: o CBC tem afinidade muito baixa por CB1 — daí a ausência de efeito psicoativo — e age sobretudo em canais TRP, particularmente o TRPA1, envolvidos na percepção de estímulos térmicos e químicos. Também interfere na degradação da anandamida.

É derivado do CBC-a, sua forma ácida na planta fresca.

No acervo

O acervo do Cannabis Indica reúne 110 estudos científicos que tocam o composto Canabicromeno (CBC), publicados entre 1970 e 2024. Pela leitura automatizada, 81 (74%) foram classificados como favoráveis, 20 (18%) como inconclusivos e 9 (8%) como desfavoráveis — uma leitura de máquina, feita para navegar, não para concluir. O desenho mais frequente é metanálise (46 estudos), seguido de estudo laboratorial (37). As condições mais associadas são Inflamação, Câncer e Dor.

Estudos indexados
110
Período coberto
1970–2024
Favoráveis
81 · 74%
Inconclusivos
20 · 18%
Desfavoráveis
9 · 8%
Termo original
Cannabichromene (CBC)

O acervo em números

Tipo de estudo

Metanálise46
Estudo Laboratorial37
Estudo em Animais19
Ensaio Clínico Duplo-Cego5
Ensaio Clínico3

Direção do resultado

Favorável81
Inconclusivo20
Desfavorável9

Por década

1970s1
1980s2
2000s6
2010s23
2020s78

110 estudos

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  1. 2024

    A systematic review of novel cannabinoids and their targets: Insights into the significance of structure in activity

    InconclusivoMetanáliseAnandamida (AEA)Endocanabinoide (não especificado)+3
  2. 2024

    Anticancer effect of minor phytocannabinoids in preclinical models of multiple myeloma

    FavorávelEstudo em AnimaisCâncer — MielomaCanabigerol (CBG)Canabinol (CBN)+1
  3. 2023

    Biotechnological Fungal Platforms for the Production of Biosynthetic Cannabinoids

    FavorávelEstudo LaboratorialDorCâncerInflamaçãoTetraidrocanabinol (THC)THC Farmacêutico+25
  4. 2023

    Cannabichromene Induces Neuronal Differentiation in NSC-34 Cells: Insights from Transcriptomic Analysis

  5. 2023

    Cannabidiol repairs behavioral and brain disturbances in a model of fetal alcohol spectrum disorder

    FavorávelEstudo em AnimaisAnsiedadeDepressãoDisfunção Cognitiva+5
  6. 2023

    Cannabidiol: Bridge between Antioxidant Effect, Cellular Protection, and Cognitive and Physical Performance

  7. 2023

    Could cannabinoids provide a new hope for ovarian cancer patients?

  8. 2023

    Effects of Cannabidiol on Innate Immunity: Experimental Evidence and Clinical Relevance

    FavorávelMetanáliseCâncerInflamaçãoAnsiedadeCanabigerol (CBG)Canabinol (CBN)+20
  9. 2023

    The antinociceptive activity and mechanism of action of cannabigerol

  10. 2023

    The Effect of Cannabis Plant Extracts on Head and Neck Squamous Cell Carcinoma and the Quest for Cannabis-Based Personalized Therapy

    FavorávelEstudo LaboratorialCâncerCâncer — Escamoso de Cabeça e Pescoço
  11. 2023

    The Safety and Comparative Effectiveness of Non-Psychoactive Cannabinoid Formulations for the Improvement of Sleep: A Double-Blinded, Randomized Controlled Trial

    FavorávelEnsaio Clínico Duplo-CegoEfeitos Adversos da CannabisPsicoseInsônia e Distúrbios do SonoCanabinol (CBN)
  12. 2022

    A Review on the Bioactivity of Cannabinoids on Zebrafish Models: Emphasis on Neurodevelopment

    FavorávelMetanáliseDorCâncerAnsiedadeAnandamida (AEA)Tetraidrocanabinol (THC)+25
  13. 2022

    Anti-cancer properties of cannflavin A and potential synergistic effects with gemcitabine, cisplatin, and cannabinoids in bladder cancer

    FavorávelEstudo LaboratorialCâncerCâncer — BexigaOutros Compostos Relacionados
  14. 2022

    Cannabis for Medical Use: Versatile Plant Rather Than a Single Drug

  15. 2022

    Cannabis sativa Extract Induces Apoptosis in Human Pancreatic 3D Cancer Models: Importance of Major Antioxidant Molecules Present Therein

  16. 2022

    Cannabis Use and the Endocannabinoid System: A Clinical Perspective

  17. 2022

    Cannabis vaping: existing and emerging modalities, chemistry, and pulmonary toxicology

  18. 2022

    Cannabis-Based Products for the Treatment of Skin Inflammatory Diseases: A Timely Review

    FavorávelMetanáliseDorCâncerInflamaçãoAnandamida (AEA)Tetraidrocanabinol (THC)+28
  19. 2022

    Cutaneous Squamous Cell Carcinoma and Lichen Simplex Chronicus Successfully Treated with Topical Cannabinoid Oil: A Case Report and Summary of Cannabinoids in Dermatology

  20. 2022

    Effects of Rare Phytocannabinoids on the Endocannabinoid System of Human Keratinocytes

    FavorávelEstudo LaboratorialDoenças de PeleAnandamida (AEA)Endocanabinoide (não especificado)+7
  21. 2022

    Effects of rich cannabidiol oil on behavioral disturbances in patients with dementia: A placebo controlled randomized clinical trial

    FavorávelEnsaio Clínico Duplo-CegoAnandamida (AEA)Tetraidrocanabinol (THC)+3
  22. 2022

    Fetal Exposure to Cannabis and Childhood Metabolic Outcomes: The Healthy Start Study

    DesfavorávelEnsaio ClínicoDiabetesSíndrome MetabólicaGestaçãoCanabigerol (CBG)Canabinol (CBN)+1
  23. 2022

    Geotemporospatial and causal inferential epidemiological overview and survey of USA cannabis, cannabidiol and cannabinoid genotoxicity expressed in cancer incidence 2003-2017: part 1 - continuous bivariate analysis

    DesfavorávelMetanáliseCâncerCanabigerol (CBG)Canabinol (CBN)
  24. 2022

    In Silico Binding Analysis of Cannabinoids with Eph Receptors for Therapeutic Use in Gliomas

    FavorávelEstudo LaboratorialCâncerCâncer — CérebroCanabidivarina (CBDV)
  25. 2022

    In vitro evaluation of the interaction of the cannabis constituents cannabichromene and cannabichromenic acid with ABCG2 and ABCB1 transporters

    FavorávelEstudo LaboratorialCâncerInflamaçãoDepressãoÁcido Canabicromênico (CBC-a)+2
  26. 2022

    In vitro percutaneous absorption studies of cannabidiol using human skin: Exploring the effect of drug concentration, chemical enhancers, and essential oils

    FavorávelEstudo LaboratorialDorCâncerInflamaçãoAnandamida (AEA)2-Araquidonoilglicerol (2-AG)+14
  27. 2022

    Industrial Hemp ( Cannabis sativa L.) Inflorescences as Novel Food: The Effect of Different Agronomical Practices on Chemical Profile

    InconclusivoEstudo LaboratorialCanabigerol (CBG)Canabinol (CBN)+3
  28. 2022

    Inhibitory Effects of Cannabinoids on Acetylcholinesterase and Butyrylcholinesterase Enzyme Activities

    InconclusivoEstudo LaboratorialCanabigerol (CBG)Canabinol (CBN)+3
  29. 2022

    Involvement of the cannabinoid system in chronic inflammatory intestinal diseases: opportunities for new therapies

  30. 2022

    Mechanisms of Cannabidiol (CBD) in Cancer Treatment: A Review

  31. 2022

    Opioid-sparing effect of cannabinoids for analgesia: an updated systematic review and meta-analysis of preclinical and clinical studies

  32. 2022

    Pharmacokinetics of cannabichromene in a medical cannabis product also containing cannabidiol and Δ9-tetrahydrocannabinol: a pilot study

    FavorávelEnsaio Clínico Duplo-CegoDorInflamaçãoDepressãoTetraidrocanabinol (THC)Monoacilglicerol Lipase (MAGL)+2
  33. 2022

    Pharmacological Aspects and Biological Effects of Cannabigerol and Its Synthetic Derivatives

  34. 2022

    Phytocannabinoid Compositions from Cannabis Act Synergistically with PARP1 Inhibitor against Ovarian Cancer Cells In Vitro and Affect the Wnt Signaling Pathway

  35. 2022

    Post-Harvest Operations to Generate High-Quality Medicinal Cannabis Products: A Systemic Review

    InconclusivoMetanáliseCanabigerol (CBG)Canabinol (CBN)+2
  36. 2022

    Profiling Cannabinoid Contents and Expression Levels of Corresponding Biosynthetic Genes in Commercial Cannabis (Cannabis sativa L.) Cultivars

    InconclusivoEstudo LaboratorialTetraidrocanabinol (THC)Canabigerol (CBG)+8
  37. 2022

    Regulating for Safety: Cannabidiol Dose in Food: A Review

    DesfavorávelMetanáliseCanabigerol (CBG)Canabinol (CBN)+5
  38. 2022

    Role of Caryophyllane Sesquiterpenes in the Entourage Effect of Felina 32 Hemp Inflorescence Phytocomplex in Triple Negative MDA-MB-468 Breast Cancer Cells

    FavorávelEstudo LaboratorialCâncerCâncer — Mama
  39. 2022

    Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations

  40. 2022

    Sex differences in medical cannabis-related adverse effects

  41. 2022

    Synthetic Strategies for Rare Cannabinoids Derived from Cannabis sativa

    InconclusivoEstudo LaboratorialCanabigerol (CBG)Delta-8-THC+1
  42. 2022

    The Medicinal Natural Products of Cannabis sativa Linn.: A Review

  43. 2021

    A Change in Blood Carbamazepine Levels Associated With Cannabis Use: Implications for Clinical Practice

  44. 2021

    A potential role for cannabichromene in modulating TRP channels during acute respiratory distress syndrome

    FavorávelEstudo em AnimaisCOVID-19EstresseSíndrome do Desconforto Respiratório Agudo
  45. 2021

    A validated method for the simultaneous quantification of cannabidiol, Δ9 -tetrahydrocannabinol, and their metabolites in human plasma and application to plasma samples from an oral cannabidiol open-label trial

    FavorávelEstudo LaboratorialAnsiedadeDor — CrônicaEpilepsia
  46. 2021

    An Evaluation of Understudied Phytocannabinoids and Their Effects in Two Neuronal Models

  47. 2021

    Antioxidant function of phytocannabinoids: Molecular basis of their stability and cytoprotective properties under UV-irradiation

    FavorávelEstudo LaboratorialEstresse OxidativoCanabigerol (CBG)Canabinol (CBN)
  48. 2021

    Cannabichromene, Related Phytocannabinoids, and 5-Fluoro-cannabichromene Have Anticonvulsant Properties in a Mouse Model of Dravet Syndrome

  49. 2021

    Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response

    FavorávelEstudo LaboratorialCâncerInflamaçãoCOVID-19Canabigerol (CBG)Ácido Canabidiólico (CBD-a)+1
  50. 2021

    Cannabigerol and cannabichromene in Cannabis sativa L.

  51. 2021

    Cannabinoid exposure as a major driver of pediatric acute lymphoid Leukaemia rates across the USA: combined geospatial, multiple imputation and causal inference study

  52. 2021

    Cannabinoids modulate food preference and consumption in Drosophila melanogaster

  53. 2021

    Cannabis and Autoimmunity: Possible Mechanisms of Action

  54. 2021

    Cannabis sativa: Interdisciplinary Strategies and Avenues for Medical and Commercial Progression Outside of CBD and THC

    FavorávelMetanáliseAnandamida (AEA)2-Araquidonoilglicerol (2-AG)+17
  55. 2021

    Cannabis-Derived Compounds Cannabichromene and Δ9-Tetrahydrocannabinol Interact and Exhibit Cytotoxic Activity against Urothelial Cell Carcinoma Correlated with Inhibition of Cell Migration and Cytoskeleton Organization

    FavorávelEstudo LaboratorialCâncerCâncer — BexigaTetraidrocanabinol (THC)
  56. 2021

    Detectability of cannabinoids in the serum samples of cannabis users: Indicators of recent cannabis use? A follow-up study

    FavorávelEnsaio ClínicoCanabigerol (CBG)Canabinol (CBN)+7
  57. 2021

    Development and Optimization of Supercritical Fluid Extraction Setup Leading to Quantification of 11 Cannabinoids Derived from Medicinal Cannabis

    InconclusivoEstudo LaboratorialTetraidrocanabinol (THC)Canabigerol (CBG)+7
  58. 2021

    Differential Interactions of Selected Phytocannabinoids with Human CYP2D6 Polymorphisms

    InconclusivoEstudo LaboratorialAnandamida (AEA)Tetraidrocanabinol (THC)+3
  59. 2021

    Dose-Related Inhibition of Capsaicin Responses by Cannabinoids CBG, CBD, THC and their Combination in Cultured Sensory Neurons

    FavorávelEstudo LaboratorialDorDor — CrônicaDor — AgudaCanabigerol (CBG)Capsaicina (CAPS)
  60. 2021

    Epidemiological overview of multidimensional chromosomal and genome toxicity of cannabis exposure in congenital anomalies and cancer development

    DesfavorávelMetanáliseCâncerCâncer — MamaCâncer — LeucemiaCanabigerol (CBG)+4
  61. 2021

    Identification of Chemotypic Markers in Three Chemotype Categories of Cannabis Using Secondary Metabolites Profiled in Inflorescences, Leaves, Stem Bark, and Roots

    FavorávelEstudo LaboratorialÁcido Canabidiólico (CBD-a)Tetraidrocanabivarina (THCV)+1
  62. 2021

    Minor Cannabinoids: Biosynthesis, Molecular Pharmacology and Potential Therapeutic Uses

    FavorávelMetanáliseCanabigerol (CBG)Canabinol (CBN)+3
  63. 2021

    Perinatal Cannabis Exposures and Autism Spectrum Disorders

    InconclusivoMetanáliseNáusea e VômitoGestaçãoAutismo+1
  64. 2021

    Pharmacokinetics and Perceptions of Children and Young Adults Using Cannabis for Attention-Deficit/Hyperactivity Disorder and Oppositional Defiant Disorder: Protocol for a Mixed Methods Proof-of-Concept Study

    FavorávelMetanáliseAnsiedadeDepressãoTranstornos de Comportamento+1
  65. 2021

    Quantitation of Δ8-THC, Δ9-THC, Cannabidiol, and Ten Other Cannabinoids and Metabolites in Oral Fluid by HPLC-MS/MS

    InconclusivoEstudo LaboratorialCanabigerol (CBG)Canabinol (CBN)+3
  66. 2021

    Terpenoids Commonly Found in Cannabis sativa Do Not Modulate the Actions of Phytocannabinoids or Endocannabinoids on TRPA1 and TRPV1 Channels

    DesfavorávelEstudo LaboratorialAnandamida (AEA)2-Araquidonoilglicerol (2-AG)+5
  67. 2021

    The antimicrobial effect behind Cannabis sativa

    FavorávelMetanáliseInfecções BacterianasAnandamida (AEA)Canabigerol (CBG)+5
  68. 2021

    The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis

  69. 2021

    The Current and Potential Application of Medicinal Cannabis Products in Dentistry

  70. 2020

    A systematic review of minor phytocannabinoids with promising neuroprotective potential

  71. 2020

    Attenuation of Oxidative Stress by Cannabinoids and Cannabis Extracts in Differentiated Neuronal Cells

  72. 2020

    Cannabinoids and Cannabinoid Receptors: The Story so Far

    InconclusivoMetanáliseAnandamida (AEA)2-Araquidonoilglicerol (2-AG)+5
  73. 2020

    Comparison of Efficacy of Cannabinoids versus Commercial Oral Care Products in Reducing Bacterial Content from Dental Plaque: A Preliminary Observation

    FavorávelEstudo LaboratorialCáriesCanabigerol (CBG)Canabinol (CBN)+1
  74. 2020

    In vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa

    InconclusivoEstudo LaboratorialCanabigerol (CBG)Ácido Canabidiólico (CBD-a)+3
  75. 2020

    Ingestion of a THC-Rich Cannabis Oil in People with Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

    FavorávelEnsaio Clínico Duplo-CegoDorDepressãoInsônia e Distúrbios do SonoCanabigerol (CBG)Canabinol (CBN)+3
  76. 2020

    It Is Our Turn to Get Cannabis High: Put Cannabinoids in Food and Health Baskets

    FavorávelMetanáliseTHC FarmacêuticoTHC:CBD Farmacêutico+4
  77. 2020

    Synergistic Cytotoxic Activity of Cannabinoids From cannabis sativa Against Cutaneous T-cell Lymphoma (CTCL) in-vitro and ex-vivo

    FavorávelEstudo LaboratorialCâncerCâncer — LinfomaCanabigerol (CBG)
  78. 2020

    The Influence of Hemp Extract in Combination with Ginger on the Metabolic Activity of Metastatic Cells and Microorganisms

  79. 2019

    Cannabichromene is a cannabinoid CB2 receptor agonist

  80. 2019

    Dosage Related Efficacy and Tolerability of Cannabidiol in Children With Treatment-Resistant Epileptic Encephalopathy: Preliminary Results of the CARE-E Study

    FavorávelEnsaio ClínicoEpilepsiaEpilepsia — Síndrome de Dravet
  81. 2019

    Simultaneous Quantification of 13 Cannabinoids and Metabolites in Human Plasma by Liquid Chromatography Tandem Mass Spectrometry in Adult Epilepsy Patients

    InconclusivoMetanáliseEpilepsiaTetraidrocanabinol (THC)Canabigerol (CBG)+5
  82. 2019

    The Endocannabinoid System of Animals

  83. 2018

    Anti-inflammatory Properties of Cannabidiol, a Nonpsychotropic Cannabinoid, in Experimental Allergic Contact Dermatitis.

  84. 2018

    Cannabinoids, the Heart of the Matter.

  85. 2018

    Medical marijuana for urologic chronic pelvic pain.

    FavorávelMetanáliseCistiteTetraidrocanabinol (THC)
  86. 2018

    Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs.

    FavorávelEstudo em AnimaisAplicações VeterináriasTetraidrocanabinol (THC)Canabigerol (CBG)+1
  87. 2017

    Molecular Targets of the Phytocannabinoids-A Complex Picture

    InconclusivoMetanáliseTetraidrocanabinol (THC)Canabigerol (CBG)+3
  88. 2017

    Recent advances in the endocrinology of the sebaceous gland

  89. 2016

    An Orally Active Cannabis Extract with High Content in Cannabidiol attenuates Chemically-induced Intestinal Inflammation and Hypermotility in the Mouse.

  90. 2016

    Cannabinoids, Inflammation, and Fibrosis

  91. 2015

    Effect of Non-psychotropic Plant-derived Cannabinoids on Bladder Contractility: Focus on Cannabigerol

    FavorávelEstudo LaboratorialCistiteCanabigerol (CBG)
  92. 2015

    The Effect of Phytocannabinoids on Airway Hyper-Responsiveness, Airway Inflammation, and Cough.

    FavorávelEstudo em AnimaisTosseTetraidrocanabinol (THC)Canabinoides Sintéticos AM-x+4
  93. 2014

    TRP Channel Cannabinoid Receptors In Skin Sensation, Homeostasis, And Inflammation

    FavorávelMetanáliseAcneSeborreiaCanabigerol (CBG)
  94. 2013

    Analysis of cannabis seizures in NSW, Australia: cannabis potency and cannabinoid profile

  95. 2013

    Non-THC Cannabinoids Inhibit Prostate Carcinoma Growth In Vitro And In Vivo: Pro-apoptotic Effects And Underlying Mechanisms

    FavorávelEstudo em AnimaisCâncerCâncer — PróstataCanabigerol (CBG)Canabinol (CBN)+4
  96. 2012

    Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice

  97. 2011

    Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes.

  98. 2011

    Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action

    FavorávelEstudo em AnimaisDorDor — NociceptivaAnandamida (AEA)2-Araquidonoilglicerol (2-AG)+2
  99. 2010

    Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.

    FavorávelEstudo em AnimaisDepressãoTetraidrocanabinol (THC)Canabigerol (CBG)+1
  100. 2010

    Disposition of cannabichromene, cannabidiol, and Δ⁹-tetrahydrocannabinol and its metabolites in mouse brain following marijuana inhalation determined by high-performance liquid chromatography-tandem mass spectrometry

    FavorávelEstudo em Animais
  101. 2010

    Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by Δ(9)-tetrahydrocannabinol

  102. 2009

    Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation

  103. 2008

    Antibacterial Cannabinoids from Cannabis sativa: A Structure−Activity Study.

    FavorávelEstudo LaboratorialInfecção por EstafilococosTetraidrocanabinol (THC)Canabigerol (CBG)+1
  104. 2006

    Anti-tumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma

  105. 2005

    Cannabis sativa and dystonia secondary to Wilson's disease.

    FavorávelMetanáliseDoença de WilsonTetraidrocanabinol (THC)
  106. 2005

    Neurophysiological and subjective profile of marijuana with varying concentrations of cannabinoids

    InconclusivoEnsaio Clínico Duplo-Cego
  107. 2005

    Therapeutic opportunities through modulation of the endocannabinoid system

  108. 1981

    Biological activity of cannabichromene, its homologs and isomers

    FavorávelEstudo em AnimaisDorInfecções BacterianasInfecções Fúngicas
  109. 1981

    Perinatal exposure to cannabichromene and delta 9-tetrahydrocannabinol: separate and combined effects on viability of pups and on male reproductive system at maturity

    InconclusivoEstudo em AnimaisGestaçãoInfertilidade MasculinaTetraidrocanabinol (THC)
  110. 1970

    Chemical basis of hashish activity

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Perguntas frequentes

Quantos estudos sobre canabicromeno (cbc) estão indexados no acervo?
São 110 estudos, publicados entre 1970 e 2024. O acervo inteiro tem 7.640 registros.
Que tipos de estudo predominam?
Metanálise: 46 · Estudo Laboratorial: 37 · Estudo em Animais: 19 · Ensaio Clínico Duplo-Cego: 5 · Ensaio Clínico: 3. A classificação segue o desenho declarado na fonte.
O que significa a classificação de resultado?
É uma leitura automatizada da conclusão de cada estudo, em três direções — favorável, inconclusivo e desfavorável. Aqui são 81 favoráveis, 20 inconclusivos e 9 desfavoráveis. Serve para navegar o acervo, não para concluir nada clinicamente: a conclusão válida é a do artigo original.

Como citar esta página

ABNT

CANNABIS INDICA. Canabicromeno (CBC) — estudos científicos sobre cannabis. 2026. Disponível em: https://cannabisindica.com.br/canabinoide/canabicromeno-cbc/. Acesso em: 13 set. 2026.

APA

Cannabis Indica. (2026). Canabicromeno (CBC) — estudos científicos sobre cannabis. https://cannabisindica.com.br/canabinoide/canabicromeno-cbc/

Esta página é um índice de acesso. Ao usar um estudo como evidência, cite o artigo original — o link de cada registro leva à fonte.